Lupus Jie Du Decoction Combined With Glucocorticoids In The Treatment Of Moderate Activity Of Systemic Lupus Erythematosus Clinical Studies

Obiective:To observe the application of alternative immunosuppressive therapy to moderate Lupus detoxification decoction active clinical treatment of patients with systemic lupus erythematosus Bed performance and serum creatinine, urine protein C-reactive protein and quantitative changes to provide the scientific basis for clinical efficacy.Methods:Specialist out-patient and in-patient selection 62 cases diagnosed as systemic lupus erythematosus, American Rheumatism Association in 1997 and enacted in accordance with systemic lupus erythematosus (SLE) activity integration points, identified as moderately active SLE, or Yin-TCM Syndrome true heat Syndrome patients. Randomly divided into two groups, the treatment group of 32 patients with lupus choose medicine decoction, a day to pay three times/day, each 150ml～200ml sugar corticosteroid prednisolone was0.4 days. The control group of 30 patients using cyclophosphamide (CTX) 10mg/kg, plus saline 250ml, intravenously once / day and continued for 2-4 days and then every two weeks and treatment in January (January to share 4). Meanwhile plus prednisone was0.4 days. After two months of observation and treatment of patients with clinical symptoms, signs, liver, kidney function, blood levels of C-reactive protein, urine protein changes.Result:1.Combined treatment with glucocorticoid moderately active SLE comprehensive clinical efficacy.Lupus detoxification decoction for treatment of complete remission rate of 46.88%, 46.88% partial response rate. void 6.25%, with a total effective rate of complete remission rate of 36.67% 93.75 % cyclophosphamide group. partial remission rate of 53.33%, 13.33% inefficient, with a total effective rate of 86.67%, statistically, no significant difference (P＞0.05). show lupus detoxification decoction with glucocorticoid treatment of moderately active SLE Clinical hydrocortisone and cyclophosphamide - considerable.2.Treatment of the clinical symptoms of SLE.Observed in patients treated with fever, muscle and joint pain, facial erythema, skin rash alopecia, a war of words broke perturbing effects of dry mouth symptoms, Ridit analysis, in a fever, muscle dysfunction, joint pain, hair loss and dry mouth, nerve symptoms, P＜0.05 shows two drugs for the treatment of symptoms have improved significantly over, But facial erythema, skin rash words erosive effect no significant difference in symptom improvement (P＞0.05).3.The two groups both serum creatinine and urinary protein CRP 24 and change. Treatment group and control group of patients treated with serum creatinine and urinary protein CRP 24 quantitative and statistical. There were significant difference, P＜0.01, compared between the two groups after treatment, serum creatinine and serum CRP levels, no significant differences p＞0.05, but 24-hour urinary protein significant difference, P＜0.01, the treatment group showed improvement in urinary protein side effects than the control group.4.Vice response to the drugs between the two groups.Two months in drug treatment to the occurrence of adverse reactions such as: central obesity, bacteria and viruses and fungal infections, neuropsychiatric symptoms of gastrointestinal reaction, alopecia increased white blood cell decrease, hyperglycemia, increased blood GPT, statistically, a significant difference, P＜0.05, suggesting that the toxicity of the treatment group was significantly less than the control group.Conclusion:Chinese joint glucocorticoid treatment of lupus detoxification decoction moderately active SLE patients with precise, SLE sugar corticosteroid treatment with cyclophosphamide, compared efficacy equal to or better than the latter, and significantly reduce drug reactions.