-volt Cold Particle Treatment Of Angina Pectoris Congenital Volt Cold Syndrome Clinical Observation And Experimental Study On Effects Of Serum Inflammatory Cytokines In Il-6, Tnf-alpha Expression

professor huang yongsheng has put forward hypothesis as"men and women conbine together,deficiency of yang,cold hidden in the asthenia part"and proposed the etiology of chinese medicine theory Pathogenic Incubative cold.He also evolved corresponding therapeutic methods and Herbs.Such methods and herbs had definite therapeutic effect on Coronary heart disease.Purpose:through randomized controlled trial,to evaluate the effects of fu han with xuefuzhuyu granular preparation in the treatment of CHD with angina pectoris of Pathogenic Incubative cold syndrome,according to Prescription-Syndrome Corresponding Theory,study the clinical manifestation of Pathogenic Incubative cold syndrome.observe and investigate the inflammation factors in blood of patients of Pathogenic Incubative cold and blood stasis syndrome.Method:60 patients of stable angina pectoris accoreded with diagnostic standards were selected and divided by randomly single blind into experiment group (30 cases),control group (30 cases),Fu han granulationes and xuefuzhuyu granulationes was dosed twice a day in experiment group,30 cases in experiment group were given Fu han granulationes and xuefu zhuyu granulationes 1 bag,twice a day. Fu han granulationes and xuefuzhuyu granulationes was dosed twice a day,jinkuishenqiwan 10 pills was dosed twice a day in control group.30 cases in control group were given Fu han granulationes and xuefuzhuyu granulations,1 bag,twice a day,jinkuishenqiwan,10 pills,twice a day.The treatment courses of the two groups lasted 28 days.To observe the sings and symptoms of angina pectoris,Pathogenic Incubative cold syndrome and blood stasis syndrome,electrocardiogram(ECG),the adverse effect,security test. to detect the serum level of TNF-α,IL-6 with the ELISA Examination.Result:experiment group has a better effect than control group in The clinical curative effect,and The clinical curative effect of angina pectoris,and The Symptom score of angina pectoris before treatment,14days and28 days. The clinical curative effect of ECG and discontinue rate of nitroglycerin,The experiment group compare with the control group,there was no significant difference. experiment group has a better effect than control group in The curative effect in clinical symptoms of traditional chinese medicine,and The Symptom score of Pathogenic Incubative cold syndrome and blood stasis syndrome. experiment group has good effects on improving the clinical symptoms of Pathogenic Incubative cold syndrome and blood stasis syndrome such as chest pain,Dyspnea,cold feet,fatigue,Vexation,preference for sighing,mouth dryness,soreness of waist,stomachache. All the patients in two groups have no obvious adverse effects .The group which given the treatment all improve the serum level of IL-6 and TNF-αafter 28 days,but the experiment group which given the fu han with xuefuzhuyu granular preparation has better effect on improve the serum level of TNF-αin blood.Conclusion:according to Prescription-Syndrome Corresponding Theory,the clinical manifestation of Pathogenic Incubative cold syndrome in accord with the results of retrospective studies. Pathogenic Incubative cold syndrome- Qi(yang)Deficiency and Qi Stagnation,mixture of cold and heat syndrome-adjust yin and yang,regulate cold and heat-fu han prescription,it is a logical chain. If considering the importance of congenital Incubative cold,we Can improve the clinical effects of CHD. fu han with xuefuzhuyu granular preparation can improve the high serum level of IL-6 and TNF-α.