Study On Dealing With The Treatment Of Coronary Heart Disease According To Congenital Latent Cold And Its Correlated With Correlative Factors Of Neuro-endocrine-immunity Network

Study on dealing with the treatment of coronary heart disease according to congenital latent cold and its correlated with correlative factors of neuro-endocrine-immunity networkCoronary heart disease(CHD) is a common and frequent disease of Cardiovascular System. It becomes the hotspot and focal point of fundamental and clinical research. Based on many years of clinical practice experience, professor huang yonghseng has put forward hypothesis as"men and women conbine together, deficiency of yang , cold hidden in the asthenia part"and proposed the etiology of chinese medicine theory: congenital latent cold. He also evolved corresponding therapeutic methods and Herbs. Such methods and herbs had definite therapeutic effect on CHD. This article sudy the"congenital latent cold"of CHD on such aspects as theory study, Retrospective Clinical Analysis, and detect correlation factor of neuro-endocrine-immunity network. Theoretical discussionThis part has discussed the clinical fundation of the proposal on"congenital latent cold"etiology theory according to clinical practice . applying the chinese medicine theory and reference to the recent development on science of syndrome , we discuss the the syndrome characteristics of pathogenic incubative cold, that is Qi(yang) Deficiency and Qi Stagnation, mixture of cold and heat syndrome. We also described the theoretical and clinical significance about the proposal of pathogenic incubative cold. and at last we analyzed the composing prescriptions and drug administering characteristics of fu han prescription which is the main clinical study treating the pathogenic incubative cold syndrome.1. Retrospective studies on clinical characteristics of congenital latent cold Syndrome in coronary heart disease with angina pectoris.Purpose: according to clinical practice, study the syndrome characteristics of"congenital latent cold"syndrome, analysis the main symptoms and signs,by using clinical epidemiological and mathematical statistics methods. To provide reference for differentiation of symptoms and signs of standardization.Method: :adopt patient service case of Coronary atherosclerotic heart disease, according to the decide of professor huang yongsheng, divided into experiment group and control group according to if the patient has Pathogenic Incubative cold syndrome. Gathet the symptoms and signs, adopt frequence analysis, factor analysis, cluster analysis and Logistic regression analysis.Result:①Patients of"congenital latent cold"syndrome have cold feet or cold limbs,and distinctive age rule.②the syndrome characteristics of"congenital latent cold"is Qi(yang) Deficiency and Qi Stagnation, mixture of cold and heat syndrome. It also can combine with blood stasis and phlegm.③Some symptom such as vexation, mouth dryness, preference for sighing, light purplish tongue, fatigue, pulse deep and weakened have a biggish contribution degree for differentiate the syndrome characteristics of"congenital latent cold".Conclusion: by analyzing the results of mathematical statistics using chinese medicine theory, we can obtain the relatively objective clinical manifestation of"congenital latent cold"syndrome. The method is an effective method for differentiation of symptoms and signs of standardization. It worth further explore.2. Clinical mechanism studies of fu han granular preparation on treatment of coronary heart disease with angina pectoris1) Clinical studies of congenital latent cold and blood stasis syndrome. of coronary heart disease with Angina PectorisPurpose: through randomized controlled trial, to evaluate the effects of fu han with xuefuzhuyu granular preparation in the treatment of CHD with angina pectoris of"congenital latent cold"syndrome,according to Prescription-Syndrome Corresponding Theory, study the clinical manifestation of Pathogenic Incubative cold syndrome.Method: 60 patients with stable angina pectoris accoreded with diagnostic standards were selected and divided by randomly single blind into experiment group (30 cases), control group (30 cases),Fu han granulationes and xuefuzhuyu granulationes was dosed twice a day in experiment group,30 cases in experiment group were given Fu Han granulationes and XueFu ZhuYu granulationes 1 bag, twice a day. Fu Han granulationes and XueFu ZhuYu granulationes was dosed twice a day, JinKui ShenQi pills 10 pills was dosed twice a day in control group.30 cases in control group were given Fu Han granulationes and XueFu ZhuYu granulationes, 1 bag, twice a day ,JinKui ShenQi pills,10 pills,twice a day.The treatment courses of the two groups lasted 28 days.To observe the sings and symptoms of angina pectoris, Pathogenic Incubative cold syndrome and blood stasis syndrome, electrocardiogram(ECG), the adverse effect, security test.Result: Experiment group has a better effect than control group in The clinical curative effect, and The clinical curative effect of angina pectoris, and The Symptom score of angina pectoris before treatment ,14days and28 days. The clinical curative effect of ECG and discontinue rate of nitroglycerin, The experiment group compare with the control group,there was no significant difference. experiment group has a better effect than control group in The curative effect in clinical symptoms of traditional chinese medicine, and The Symptom score of congential latent cold syndrome and blood stasis syndrome. experiment group has good effects on improving the clinical symptoms of congential latent cold syndrome and blood stasis syndrome such as chest pain, dyspnea, cold feet,fatigue ,vexation, preference for sighing,mouth dryness, soreness of waist, stomachache. All the patients in two groups have no obvious adverse effects .Conclusion: according to Prescription-Syndrome Corresponding Theory, the clinical manifestation of congential latent cold syndrome in accord with the results of retrospective studies. congential latent cold syndrome- Qi(yang)Deficiency and Qi Stagnation, mixture of cold and heat syndrome-adjust yin and yang ,regulate cold and heat-fu han prescription,it is a logical chain. If considering the importance of congential latent cold, we Can improve the clinical effects of CHD. 2) Clinical studies of yang Deficiency and blood stasis syndrome of coronary heart disease with angina pectorisPurpose: through randomized controlled trial, to evaluate the effects of Fu Han with XueFu ZhuYu granular preparation in the treatment of coronary heart disease with angina pectoris of yang Deficiency and blood stasis syndrome.Method: 60 patients of stable angina pectoris accoreded with diagnostic standards were selected and divided by randomly into experiment group (30 cases), control group (30 cases),Fu Han granulationes and XueFu ZhuYu granulationes was dosed twice a day in experiment group,30 cases in experiment group were given Fu Han granulationes and XueFu ZhuYu granulationes 1 bag, twice a day .Fu Han granulationes and XueFu ZhuYu granulationes was dosed twice a day,JinKui ShenQi pills ,10 pills was dosed twice a day in control group.30 cases in control group were given Fu Han granulationes and XueFu ZhuYu granulationes, 1 bag,twice a day, JinKui ShenQi pills, 10 pills, twice a day. The treatment courses of the two groups lasted 28 days. To observe the sings and symptoms of angina pectoris, yang deficiency and blood stasis syndrome, electrocardiogram(ECG), the adverse effect, security test.Result: Compare The clinical curative effect, and The clinical curative effect of angina pectoris, and The Symptom score of angina pectoris before treatment ,14 days and 28 days. The clinical curative effect of ECG and discontinue rate of nitroglycerin, The curative effect in clinical symptoms of traditional chinese medicine, there was no significant difference in two groups. experiment group has good effects on improving the clinical symptoms of yang Deficiency and blood stasis syndrome such as palpitations, breathe hard ,fatigue ,All patients in two groups have no obvious adverse effects .Conclusion: Fu Han with XueFu ZhuYu granular preparation has a similar curative effect in the treatment of CHD with angina pectoris of yang Deficiency and blood stasis syndrome with JinKui ShenQi pills plus XueFu ZhuYu granular preparation. it has good effects on improving the clinical symptoms of yang deficiency and blood stasis syndrome such as palpitations, breathe hard ,fatigue. 3. Study on the relationship between congenital latent cold and blood stasis Syndrome of CHD and correlative factors of neuro-endocrine-immunity networkPurpose: observe and investigate the correlative factors of neuro-endocrine-immunity network in blood of patients of congenital latent cold and blood stasis syndrome, yang deficiency and blood stasis syndrome. Sub-health and health people,study the the relationship between congenital latent cold syndrome of CHD and correlative factors of neuro-endocrine-immunity network.Method: 60 patients of stable angina pectoris accorded with congenital latent cold and blood stasis syndrome , 30 patients of stable angina pectoris accoreded with yang deficiency and blood stasis syndrome, 30 sub-health people accoreded with congenital latent cold and blood stasis syndrome , 30 heallth people as control group. to detect the serum level of hs-CRP, TNF-α, ACTH, IL-6 and Cortisolwith the ELISA Examination, to detect the gene expressive content of IL-6 and TNF-αin blood with Reverse Transcription–poly merasechain reaction(RT-PCR).Result: Compare with the health control group , all CHD patients have a higher serum level of IL-6,TNF-α,hs-CRP and a lower serum level of ACTH and Cortisol,they alos have a more obvious gene expressive content of IL-6 and TNF-αin blood. Sub-health people also have a higer serum level of IL-6, TNF-αand a lower serum level of ACTH and Cortisol. Compare with the group of yang Deficiency and blood stasis syndrome, all patients of congenital latent cold and blood stasis syndrome have a higher serum level of hs-CRP and a lower serum level of ACTH and Cortisol. The group which given the treatment all improve the serum level ,but the experiment group which given the Fu Han with XueFu ZhuYu granular preparation has better effect on improve the serum level of TNF-α, Cortisol, ACTH and gene expressive content of TNF-αin blood.Conclusion: The sub-health people with Pathogenic Incubative cold syndrome have potential outbreak of CHD and hypofunction of hypothalamic-pituitary-adre-nal axis, disorder of hs-CRP, ACTH, Cortisol may be part of the character of Pathogenic Incubative cold syndrome.