| Recently, many researchs report: incidence of obesity in children and adolescents is constantly ascended. Obesity effects mature of children and adolescents. But, it rarely report the mechinsm about effect of obesity on bone mature and sex mature.Objective: The purpose of this study was to investigate the influence of overweight and obesity on bone development and sex development in male adolescents, to provide reference for monitoring growth and development and preventing obesity among adolescence.Methods: According to body mass index (BMI) norm cut off points about overweight and obesity in Chinese children and adolescents, eighty male adolescents have been divided into tree groups:overweight, obesity, normal. Bone age (BA) was evaluated among each subject according to Chinese scoring method through hand and wrist radiograph. Self-assessments Secondary Sex Characteristics in each subject was used by Tanner graph and corresponding writing description. Serum estradiol and testosterone were taken with empty stomach in the morning ,then were measured. Results: CD Bone age of overweight and obesity groups issignificantly bigger than that of normal subjects (normal: 16. 00+1. 09a;overweight: 16. 73 + 1. 02a;obesity: 16. 73 + 1. lla;P<0. 01) .There has significant relationship betweet BA and BMI(r=0. 32, P<0. 01) . Pubic hair stages in overweight and obesity groups has delayed (P<0. 05) . It is not significant difference of the first age of spermatorrhea and Genital stages in three groups are not obviouslly different. The average serum estradiol levels in overweight and obesity are significantly higher than those of normal subjects (P<0.05) (normal: 22.44 + 8. 95pg/ml;overweight: 28. 10 +11. 39pg/ml;obesity: 30.32 + 13. 13pg/ml) .There is not obviously difference in the serum estradiol between overweight and obesity. There has significant relationship betweet E2and BMI (r=0. 23, P<0. 01) . There has no signifiscent difference in the serum T among three groups (normal: 370.37 + 96.89ng/dl;overweight: 349.58+ 83. 14ng/dl;obesity: 347.18 + 59.47ng/dl ) .There has significant positively relationship betweet bone age and Tanner sex characteristic in normal weight male adolescents(P<0.05);it is no relationship betweet bone age and Tanner sex characteristic in overweight and obesity male adolescents. Conclusion:Bone development is in advance in overweight and obesity male adolescents, but sex development is delayed. Theirbone development and sex development preceeds in a no parallel fashion. The reason is that ascending estradiol in the blood serm due to obesity. |
PDF Full Text Request