Exercise In Shr The Myocardial Ace2mrna, At <sub> 1 </ Sub> Mrna Expression And Mechanisms

Objective:Observation movement on the ACE2mRNA,AT₁mRNA expression of the myocardial of hypertensive rats, and to explore appropriate exercise on the prevention of complications of hypertension and effect and mechanism for the prevention and treatment of hypertension and its complications and provide a theoretical basis.Methods:16 male SHR rats, eight Wistar rats (group C), SHR rats were randomly divided into quiet control group (Group S) and sports (T group) 8. T group daily 90-minute swim without load movement, the 6th week, eight weeks. Observation eight weeks after myocardial ACE2mRNA expression, myocardial AT₁mRNA, AngⅡ, NO, heart coefficient biochemical indicators of movement on hypertensive rats protection.Result:adopt 10.0 software packages of SPSS to the result:1. After eight weeks of swimming exercise, exercise group (T) SHR rat heart coefficient was significantly lower than quiet group (group S) (P <0.05); quiet group (group S) SHR rat heart coefficient than normal group (group C) Wistar rats were significantly higher (P <0.01). Hypertension factor that can increase heart, and exercise can reduce hypertension caused by the increase in the coefficient of heart.2. After eight weeks of swimming exercise, exercise group (T) AngⅡSHR rat myocardium was significantly lower than the quiet group (group S) (P <0.01); quiet group (group S) SHR rat myocardial and plasma AngⅡcontent than normal group (C) Wistar rats were significantly higher (P <0.01). At the same time, the exercise group (T) SHR rat cardiomyocytes NO NO and serum was significantly higher than the quiet group (group S) (P <0.05); quiet group (group S) SHR rat myocardium and serum NO content than normal group ( Group C) Wistar rats were significantly decreased (P <0.05, P <0.01). That hypertension can rat cardiomyocytes and plasma AngⅡincrease, but also myocardial and serum NO decreased, and exercise can reduce hypertension caused by myocardial AngⅡcontent increased, and increased hypertensive rats and serum NO content.3. After eight weeks of swimming exercise, exercise group (T) SHR rat cardiomyocytes ACE2mRNA expression was significantly higher than that quiet group (group S) (P <0.05); quiet group (group S) SHR rat cardiomyocytes ACE2mRNA expression than normal (group C group) Wistar rats were significantly decreased (P <0.01). Myocardial ACE2mRNA that hypertension can reduce the expression and exercise can be increased from hypertensive rats ACE2mRNA expression.4. After eight weeks of swimming exercise, exercise group (T) SHR rat cardiomyocytes AT₁mRNA expression was slightly lower than quiet group (group S), but no statistical significance; exercise group (T) and quiet group (group S) SHR rats AT₁mRNA myocardial expression than normal group (group C) Wistar rats were significantly higher (P <0.01). Myocardial AT₁mRNA that hypertension can increase the expression, and movement can not effectively reduce the hypertensive rats AT₁mRNA expression.Conclusion:1. The appropriateness of long-term campaign to increase blood pressure in SHR rats and the development of cardiac hypertrophy have a certain ease, because SHR rat heart and blood vessels shrink material AngⅡwas increased and its receptor AT₁mRNA expression, making AngⅡenhance the role, So that blood vessels to contract, high blood pressure, accelerate the occurrence of cardiac hypertrophy. For a long time for the campaign could increase myocardial ACE2mRNA, hypertensive rats to high concentrations of substances AngⅡvasoconstrictor to the activity of a vascular Shu Ang1-7 changes, and Ang1-7 through its own receptor Mas, AngⅡAT2 receptor As well as through the ACE and endothelial cells bradykinin (BK) 2 receptor signaling pathway cross-dialogue, to increase BK release NO, NO to play second messenger role in the cardiovascular system play a diastolic blood vessels, lowering blood pressure, inhibiting platelet aggregation, Lower blood viscosity, the Museum of resistance, and so reduce the effect of achieving the regulation of blood pressure.2. Suitable for long-term movement of the SHR rat can significantly reduce the coefficient of heart and myocardial AngⅡcontent, suggesting that long-term regular exercise can improve AngⅡmediated cardiac hypertrophy.