Preparation Of Volatile Oil Of Duxiang Cataplasm Plaster

Ledum distributed in the northeast area in China, its main focus in the Daxinganling and changbai region,is a rich plant resources.Ledum essential oil is extracted from leaves and stems of aromatic volatile oil.the study found that a significant anti-bacterial anti-inflammatory effect.Duxiang oil prepared by ultrasonic sesame oilβ-cyclodextrin,as a raw material medicine. Through the characterization experiment (microscope imaging method,TLC,UV and infrared,ect),Duxiang oil to be inclusion;measured encapsulation efficiency was 91.39%,RSD2.80%;drug loading 1.68%,RSD0.81%.Orthogonal experimental design method (L934),the peel strength for the quantitative indicators,the choice of caibomer as a reinforcing material,sodium polyacrylate as adhesives,PVPK3o and PVA as film-forming agent,glycerol as humectant,propylene glycol penetration enhancers,calcium hydroxide as a crosslinking agent,citric acid as crosslinking regulator,sesame oil preparation Duxiang cataplasm. The best formulation ratio is Carbomer:sodium polyacrylate glycerol:kaolin=1.5:5:20:1. Orthogonal experimental design method (L934),selected the best conditions:refining and time is 40min,refining and the temperature is50℃,refining and the speed of 400r/min. Orthogonal experimental design method (L934), optimal dosage of transdermal absorbent,The experiment shows 3%and 4% Azone transdermal absorption of propylene glycol the best, the highest rate of percutaneous absorption, the most significant promoting effect.Established by capillary gas chromatograph method of Duxiang cataplasma sesame oil-determination of p-cymene were the result of p-cymene,the average recovery was 99.79%.RSD0.45%,indicating that the method is more accurate and reliable.Pharmacological experiments show that:Duxiang oil cataplasm plaster has a certain antibacterial agents anti-inflammatory effect.