Experimental Research Of Decreasing Toxicity And Increasing Efficacy On The Compatibility Of Nux Vomica And Paeonia Lactiflora

Objective: this project choose different compatibility proportion of semen strychni compatibility of radix paeoniae Alba decoction to observe its effects on the toxic and analgesic effect of and discussion on its mechanism of pain.Method: this issue through acute toxicity and high performance liquid chromatographic analysis of toxicity effect of compatibility of Nux Vomica semen strychni glucosides. By hot-plate and mice in mice by twisting effect observation of its effect on the pain. Adjuvant-induced arthritis rats induced by foot through the swell rate, coefficient of immune organs of rats and rat serum MDA and SOD, NO discussion on the determination of the compatibility of semen strychni glucosides of analgesic and anti-inflammatory effects mechanism.Results: theoretical and experimental study on this subject by, certified compatible reduces glucosides of semen strychni semen strychni toxicity, enhanced semen strychni analgesic and anti-inflammatory effects, compatibility with reducing poison and increasing effect of the two. Its analgesic, anti-inflammatory mechanism is through the free radical damage and protection cells, play a role in analgesia.Conclusion: the subject believe that semen strychni compatibility to 1:6 compatibility of reducing poison and increasing effect of glucosides, and traditional view larger doses of glucosides, Nux Vomica reducing poison and increasing effect of the more consistent. At the same time the subject is also verified the correctness of the theory of traditional Chinese medicine compatibility.