Yang Xin P53 Gene Transfection Particles Of Vulnerable Plaque Apolipoprotein M Rabbit Model Of Influence Of The Content

Objective:The p53 gene transfection through the establishment of vulnerable plaque in rabbits, rabbit model of vulnerable plaque observed in serum apolipoprotein M (apoM) levels, explore Yang Xin particle stability of atherosclerotic vulnerable plaque in the exact mechanism of action, and then played the prevention and treatment of atherosclerotic disease role for the clinical application of a reliable theoretical basis.Methods:Balloon time with carotid artery injury in rabbits fed high-fat diet for 8 weeks,8 weeks Color Doppler ultrasound, the common carotid artery plaque formation of p53 gene in Rabbits were randomly divided into model control group, Yang Xin particle group, simvastatin group, each group had 6 cases; In another six as a control group; given drugordistilled water for two weeks; 10 weeks, in the execution of the first 24 hours and 48 hours viper venom injection spots and histamine drugs trigger twice, copied into a similar human atherosclerotic rabbit model of vulnerable plaque. Dose according to body surface area were converted rabbit formula measured dose of each treatment group were given drugs orally for two weeks, raising the heart pellet powder administered by 0.643g/kg/d; simvastatin group received 2.5mg/kg/d dose, the control group and model control group were fed the same volume of distilled water. Once a day. Respectively, Experiments were 8 weeks and 10 weeks by ear vein blood, using ELISA method in the composition of the blood serum levels of apoM.Results:Compared with the control group, each group in the eight weeks apoM were significantly decreased, the difference was statistically significant (P<0.01); 10 weekends, compared with the control group, each treatment group by apoM levels were increased. Yang Xin particle group and the simvastatin group was significantly (P<0.05); all treatment groups, raising the heart levels of particle group and the simvastatin group than in model control group, the difference was statistically significant (P< 0.05). Conclusion:Yang Xin particles traditional Chinese medicine can increase gene p53 rabbits vulnerable plaque apolipoprotein M levels, in order to improve atherosclerotic plaque vulnerability level, play a prevention of atherosclerotic disease role, which may raise heart particles to stabilize vulnerable plaque one of the mechanisms.