Effect Of Yangxin Granule On Serum IL-18 In Vulnerable Plaque Rabbit Model With P53 Gene Transfection

Objective:To study the effect of Yangxin granule on serum interleukin 18 (IL-18) in vulnerable plaque rabbit model with P53 gene transfection.Methods:Carotid artery wall injuries were induced an intravascular balloon in rabbits before rabbits were fed on high fat diet for 8 weeks. At the end of the 8th week, recombinant adenovirus vector by transfecting P53 gene were injected through a catheter into the carotid segments which were plaques, rabbits were randomly divided into four groups:Model control group, Yangxin granule group, simvastatin group and blank group (6 in each group).Administration for two weeks and plaque rupture because of pharmacological triggering. At the end of the 8th and 10th weekend,the content of serum IL-18 was examined.Results:Compared with blank group,the content of serum IL-18 obviously increased in other groups at the end of the 8th week(P<0.01).Compared with Model control group,the content of serum IL-18 declined in treatment groups at the end of 10th week.There was significant differ-ence between Yangxin granule group and simvastatin group (P<0.01).The content of Yangxin granule group was lower than simvastatin group(P<0.01).Conclusion:Yangxin granule remarkably decreased the content of serum interleukin 18(IL-18) in vulnerable plaque rabbit model with P53 gene transfection, which might be one of the mechanisms for stabilizing vulnerable plaque.