The Study Of Continuous Observation To Evaluate The Inorganic Active Element Bone Tissue Engineering Scaffold Materials For The Reparation And Reconstruction Of Mandibular Defects By Radiology Combined Bone Mineral Density Measurements

Objective: In recent years a variety of new bone tissue engineering scaffold materials torepair bone defects in the field of bone tissue engineering had changed the traditionaltreatment modalities for the treatment of bone defects. The core of the bone tissueengineering is to build a complex three-dimensional space composed of cells andbiological materials, form a living tissue of vitality, the morphological, structural andfunctional reparation of bone defects and to achieve a permanent replacement, willfundamentally solve the problem of bone defects. In this study, using the inorganic activeelement bone tissue engineering grafts were manufactured by the Department ofMolecular Biocompatibility in Boston University，and provided by Chinese YangShengbiological engineering Co., LTD，for the reparation and reconstruction of mandibulardefects due to the cyst or tumor volunteer patients who underwent the jaw bone defects,and evaluate the effect of the tissue engineering of bone remodeling from theradiological point of view.Methods: The experiment was carried out in our department from January2008toDecember2010.①Experiment materials: Inorganic active element bone tissueengineering grafts were provided by the Department of Molecular Biocompatibility inBoston University. Randomly selected from January2008to December2010in ourdepartment due to surgical removal of cysts or tumors69cases of patients withmandibular defects by the hospital Medical Ethics Committee approval accord with the requirements of the scientific and ethical principles.②Experimental methods: Theexperimental group were41volunteers using inorganic active element scaffoldmaterials for the bone defects reconstruction，while other28cases were served as blankcontrol group，without using the scaffold materials.③Observation index: At2、4、8、12weeks postoperatively，all volunteer patients were examined by the panoramic filmto observe the new bone formation in defect area，and were evaluated X-ray gradingscores and radiopaque density values according to the X-ray classification rating，6-points methods and X-ray resistance radiopaque density measurement standard.Results:①General observation: All patients were treated by the conventionalanti-infection postoperatively in addition to local edema they had no othercomplications occurred, and all wound healed well at I period.②X-ray observation:The radiographic score of the bone defect and new bone in the4,8, l2-week of clinicaltrials group with the application of inorganic active element bone tissue engineering swas significantly better than the blank control group without the scaffold materials，found that the tissue engineering bone show growth over time, the gradual increase inthe characteristics of bone formation, in the six months radiopaque quiescent bonemarrow reconstitution X-ray image, and the bone defects in the control group had noobvious bone reparation in l2week.Conclusion: Inorganic active element bone tissue engineering scaffold materials havegood function on auto-osteogenesis and revascularization, as well as goodbiocompatibility, so these materials will be effective prospect in clinic of repairing bonetissue engineering defects． Using radiographic examination combined with bonemineral density measurement of the bone defect reconstruction have the importantmeaning.