Study On The Comparison Of Chemical Constituents Of Cornus Officinalis Before And After Fermentation

Cornus officimalis is commonly used in clinical medicine.The drug is the dry ripe fruit of Polygonum plants, mainly distributed in Henan, Zhejiang, Shanxi, Anhui. Modern research found that Cornus officimalis contains organic acids, iridoid glycosides, saponins and other ingredients.It can promote hematopoietic function, regulate immune function, reduce blood lipid and atherosclerosis, anti-tumor, anti-oxidation, anti-aging, regulate endocrine, laxative and so on. After processing of traditional Chinese medicine, the quality and quantity of the internal components were changed, it would better serve the advantages of traditional Chinese medicine. Fermentation is one important way of processing of traditional Chinese medicine, as one of the important methods of processing, has received more and more attention of the world.9compounds were isolated from Polygonum and they were identified as β-sitosterol (Ⅰ), oleanolic acid(Ⅱ), ursolic acid (Ⅲ), daucosterol (Ⅳ), gallic acid (Ⅴ), loginin(Ⅵ), monodglycosides(Ⅶ), sweroside(Ⅷ), D-glucose (Ⅸ).In order to compare the change of pharmacological efficacy and chemical composition,we first optimized by orthogonal experiments Cornus officimalis decoction extract the best conditions.Compare the anti-oxidative activity and anti-blood glucose effect,before and after of microbial fermentation. Research the changes of the HPLC fingerprint and the changes of main chemical composition after fermentation, looking for the relationship between the pharmacological efficacy and chemical composition changes,which provide a scientific basis for the clinical drug of Cornus officimalis fermentation decoction and the development of traditional Chinese medicine fermentation.