| Objective:The acupuncture-medicine synthesizes therapy was combination of acupuncture external treatment and Wubeisan medicine for oral use. Comparing with pure west medicine,101cases patients of gastro-esophageal reflux disease (GERD) were observed with strictly designed random comparison method. The clinical validity of acupuncture-medicine synthesizes therapy on patients of GERD was observed, and furthermore its function mechanism was probed.Methods:101GERD patients of the First Hospital of Wuhan City conformed with the inclusive criteria from2011-03to2011-10were elected. According to numeration table patients randomized into the treatment group (51cases) and the control group (50cases). The treatment group took Wubeisan medicine,3g each time, half an hour before meal, tid; Acupuncture external treatment:the patients were acupunctured with various reinforcing and reducing method once per day, and acupoint selection were Zusanli (ST36), Zhongwan (RN12), Gongsun (SP4), Neiguan (P6), Yanglingquan (GB34), and Weishu (BI21). The control group took motilium10mg each time, half an hour before meal, tid. Both of the two groups took Rabeprazole10mg each time, half an hour before meal, bid. That was8weeks of treatment as one treatment period. The other stomach medicine was prohibited during treatment period. Blood, urine, faeces, liver and renal function, electrocardiogram and other conventional index were detected before and after treatment to all cases. Score the symptoms of Traditional Chinese Medicine (TCM) and compare the two groups of Chinese medicine card type curative effect and the safety examination result. Make a follow-up visit16weeks after stopping the treatment in the recovery cases, and observe recurrence situation.Results:(1)The number of participants:Differences between the two groups of patients with general information of comparison:Ridit analysis of the two groups in the number of cases, gender, age, course of disease and the number in each symptom type of TCM were comparable (P>0.05). Non of the treatment group (51cases) and the control group (50cases) have depigmentation and excluded cases. All the cases enter the final analysis.(2) Clinical curative effect comparison post-treatment:The treatment group of51cases, cured20cases,18cases markedly effective, effective in8cases,5cases invalid, and the total efficiency is90.2percent. The control group of50cases, cured13cases,15cases markedly effective, effective in11cases,11cases invalid, and the total efficiency is78.0percent. By X2test the total efficiency of comparison after treatment showing that they were significant (P<0.05). (3) Compare the symptom score:The symptom scores between the two groups before treatment were comparable (P>0.05). The symptom scores of the two groups after treatment were significantly lower than prior treatment, and the difference was significant by t-test (P<0.05).The symptom scores between the two groups after treatment was significant too (P<0.05), which means the treatment group of the clinical symptom improvement was superior to the control group.(4) Comparing the curative effect in each group of TCM symptoms, the treatment groups of liver-stomach heat syndrome, gallbladder heat invading stomach syndrome, spleen-hypofunction and reverse qi syndrome were comparable (P<0.05) by X2test. The groups of blood-stasis obstruction syndrome and qi-phlegm stagnation syndrome had no statistical significance (P>0.05) by X2test.(5) The safety examination result:the bad reaction was not discovered in the two groups of clinical trial. The abnormality phenomenon was not discovered in pre-treatment and post-treatment through the blood, urine, faeces, liver and renal function, electrocardiogram examination.(6) Recurrence situation comparision between the two groups:Make a follow-up visit16weeks after drug withdrawal in the recovery cases. The treatment group of40patients with cured therapeutic effect recurred3cases, and the recurrence rate was7.5percent. The control group of37patients with cured therapeutic effect recurred9cases, and the recurrence rate was24.3percent. The difference was significant (P<0.05)Conclusion:(1) The result of clinical contrast observation on the101cases of GERD patients showed that the acupuncture external treatment and Wubeisan medicine could improve clinical symptom of patients. The whole effective rate was90.2percent, more excellent than the west medicine group.(2)The acupuncture external treatment and Wubeisan medicine had curative effect in the treatment groups of liver-stomach heat syndrome, gallbladder heat invading stomach syndrome, spleen-hypofunction and reverse qi syndrome.(3)The treatment method of acupuncture external treatment and Wubeisan medicine on patients of GERD was safe, effective and low recurrence rate. Therefore, this clinical treatment method was worth popularizing. |
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