The Moderation Effect Of MAOA-VNTR On Relationship Between Maltreatment And Aggressive Behaviors, Impulsives Behaviors And Rule-breaking Behaviors

Objective (1) to examine whether MAOA-VNTR moderates the relationship between the child maltreatment and aggressive behaviors;(2) to examine whether MAOA-VNTR moderates the relationship between the child maltreatment and impulsive behaviors;(3) to examine whether MAOA-VNTR moderates the relationship between child maltreatment and rule-breaking behaviors.Methods In the cross-section study,586high school students completed the following3scales to assess child maltreatment, impusive behaviors, aggressive behaviors, rule-breaking behaviors:(1) Childhood Trauma Questionnaire-28item Short Form, CTQ-SF;(2) Barratt Imppulsiveness Scale11th version;(3) Achenbach Child Behavior Checklist-Youth Self-reports, CBCL-YSR. Hierarchical Regression model is used to data analysis. For all participants DNA was obtained from buccal samples. Polymerase chain reaction (PCR) was used to detect the distributive frequency of MAOA-VNTR.Results Between high and low genotypes, there have no significant differences in child maltreatments, aggressive behaviors, impulsive behaviors and rule-breaking behavior. Hierarchical Regression results showes:(1) MAOA-VNTR moderates the relationship between the emotional abusement and aggressive behaviors, rule-breaking behaviors for male adolescents (β=-0.535, P<0.05、β=-0.328, P<0.001);(2) MAOA-VNTR moderates the relationship between the sexual abuse and impulsive behaviors for male adolescents (β=2.316, P<0.05);(3) MAOA-VNTR moderates the relationship between the sexual abusement and rule-breaking behaviors for female adolescents (β=-0.624, P<0.001).Conclusion Male adolesents with low-activity MAOA genotype who suffered emotional abusement are more prone to aggressive and rule-breaking behaviors. Male adolescents with high-activity MAOA genotype who suffered sexual abusement are more prone to impulsive behaviors. Adolesents with low-activity MAOA genotype are more prone to rule-breaking behaviors for female adolescents who suffered sexual abusement.