| Objective:Under the direction of syndrome differentiation and treatment theory, this study analyse the influencing factors of reflux esophagitis (RE)1ike age,gender,degree of educat ion,occupat ion,course, incent ives, gastroscopic manifestation and TCM syndrome type. Discuss the relationship between the RE gastroscopic manifestation and TCM syndrome type.It can guide the practice and scientific research, boost the curative effect and the treatment level.Method:This thesis contains literature and clinical study. The literature review article is divided into two parts, summarizes the Chinese Medicine and Modern medicine study of RE research progress respectively. Clinical research part collects data of102cases with RE through the questionnaire and gastroscope inspect ion way. According to the digestive disease of TCM treatment guidelines, the patients are divided into six syndrome types. They are disharmony of liver and stomach, stagnant heat in liver and stomach, spleen-stomach damp-heat,qi and phlegm stagnation,weakness of the spleen and the stomach, deficiency of stomach Yin. Applying for SPSS17.0software, this study statistically analyse the various factors and their relationship.Result:1. The proportion of female pat ients is higher than male,36-55years old age group for the most, Most patients graduate above technical secondary school.2.Diet and emotional disposition factors are the most common cause.3. In the frequency of the whole cl inical symptoms, the top five are heartburn, stomachache, sour regurgi tat ion, xerostomia, bitter taste.4. On the part of endoscopic grades, the majority of patients are under Grade Ⅰ, few patients are under Grade Ⅱ and Grade Ⅲ.5. Esophageal mucosal commonly show hyperemia, oedema, and also can appear erosion and ulcer, etc. They are usually complicated by chronic superficial gastritis, erosive gastritis or bile reflux.6. The TCM syndrome type proportional from high to low in turn is stagnant heat in liver and stomach, spleen-stomach damp-heat, disharmony of liver and stomach, weakness of the spleen and the stomach, qi and phlegm stagnation,deficiency of stomach Yin. Distribution of the TCM syndrome types are statistically significant differences (P<0.01).7. The pat ients’gender and course have the statistical meaning of RE (P<0.05), age does not have the statistical meaning of RE (P>0.05).8. The distributions of the syndromes have significant difference between all grade in gastroscopy (P<0.01). Grade Ⅰ are mainly in the state of sthenia syndrome. Grade Ⅱ and Grade Ⅲ are usually in the state of asthenia syndrome.9. Helicobacter pylori(Hp) infection in TCM syndrome type distribution are statistically significant (P<0.05) Infection rate from high to low in turn is spleen-stomach damp-heat,stagnant heat in liver and stomach, deficiency of stomach Yin,qi and phlegm stagnation, disharmony of liver and stomach,weakness of the spleen and the stomach.10. Different mucous membrane performance or complications do not havesignificant correlation with TCM syndrome types (P>0.05).The difference between mucous membrane performance and tongue manifestation is statistically significant (P <0.05). Mucous membrane hyperemia, oedema, over-ef fus ion are more common in red tongue and thin yellow moss. Hacklysurface are more common in light red tongue and white greasy moss. Erosion and ulcer are more common in dark red tongue and thin yellow moss.Conclusion:1. Heartburn is the most frequency of the RE clinical symptoms. Most of the patients’ esophageal mucosa injury are minor.2. The TCM syndrome type proportion has large dfferences. Heat and sthenia syndrome are more common than asthenia syndrome.3. Female are main parts of patients with RE. Patients’gender is related to the distribution of TCM Syndrome of RE.Male usually show spleen-stomach damp-heat syndrome,and female usually show disharmony of liver and stomach syndrome. Age does not have relationship with the distribution of TCM Syndrome.4. The disease course has relationship with the distribution of TCM Syndrome. Patients with short-term course mainly show in heat and sthenia syndrome,while asthenia syndrome commonly occur in long-lasting course.5. Grade in gastroscopy is concerned with the distributions of TCM syndrome. The esophageal mucosa injury of asthenia syndrome is more serious than sthenia syndrome.6. Hp is related to the distribution of TCM Syndrome. More Hp-positive patients attribute to spleen-stomach damp-heat and stagnant heat in liver and stomach syndrome.7. Color and coating on the tongue can reflect different esophageal mucosal performance.Mucous membrane hyperemia, oedema, over-effusion are mainly caused by damp-heat syndrome. Hacklysurface are mainly caused by qi and phlegm stagnation syndrome. Erosion and ulcer are mainly caused by toxic heat and blood stasis. |
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