Researches On The Chemical Constituents From Lycii Fructus And Gardeniae Fructus And Their Biological Activities

The chemical constituents from ethyl acetate fraction of water extract of Lycii Fructus were studied. Their structures were mainly elucidated on the basis of NMR, MS and UV spectral evidences.Twelve compounds were separated and identified, including six phenolic acids:protocatechuic acid (1), dihydroisoferulic acid (2), caffeic acid (3), Z-p-hydroxy-cinnamic acid (4), E-p-hydroxy-cinnamic acid (5), trans-cinnamic acid (6); Three coumarins:scopoletin (7), isoscopoletin (8), esculetin (9); two pyrrole derivatives:4-[formyl-5-(hydroxymethyl)-1H-pyrrol-1-yl] butanoic acid (10),4-[formyl-5-(methoxymethyl)-1H-pyrrol-1-yl] butanoic acid (11);4’-hydroxyacetophenone (12). Except compounds3,5and7, others are isolated from this plant for the first time. Compounds2,4,8,9,12are firstly isolated from the genus of Lycium L Antioxidant activities and hepatoprotective activities of the compounds were evaluated and the results showed that compounds1,2,3,9had moderate antioxidant activities, compounds1,4,9had moderate hepatoprotective activities.In the present study, chemical investigation of Gardeniae Fructus led to the isolation of nine compunds, Including seven monoterpene derivatives:jasminoside U (1), epijasminoside A (2), jasminoside A (3),6-O-trans-sinapoyljasminoside B (4), geniposide (5),6a-hydroxygeniposide (6), gardenamide A (7), dibutyl phthalate (8),4’-hydroxyacetophenone (9). Compound1is a new compound.