| Purpose：Ankle arm index (ankle brachial index, ABI) is ankle artery systolic bloodpressure values divided by the humerus artery systolic blood pressure numerical resultsof[1-2]. As the check method of simple, non-invasive and repeatable, and economicapplicability, therefore it is not only widely recognition and application in clinicaldiagnosis, disease screening and is especially suitable for large populations. Clinicaldetection of ankle arm index, can be roughly screening out peripheral artery disease,peripheral arterial diseases, PAD) patients, and a better assessment of the severity of thedisease, to predict its outcome. With in-depth study of ankle arm index, also foundlower ankle arm index correlation with disease of heart head blood-vessel has[3-4]. Creaction protein (C-reactive protein, CRP) belongs to the acute instead should proteinfamily, its synthesis in the liver, the IL-6and so on under the action of inflammatoryagents that elevated serum CRP concentration, is the most sensitive of the inflammatoryprotein, its in normal serum content is low, with the development of molecular biologyand immunology, clinical can use advanced technology to detect the low concentrationof CRP, called super quick CRP (High sensitivity C-reactive protein, HsCRP). CRP asan inflammatory marker in the Acute cerebrovascular Disease (Acute Cerebral Vesseldiseases, ACVD) of development plays a very important role in the process, can reflectthe severity of Cerebral infarction; Research shows, hypersensitive c-reactive proteinlevel is higher, the acute cerebrovascular disease of nerve function damage degree, andthis kind of inflammatory markers and atherosclerotic plaque stability correlation, thehigher its concentration, the greater the instability of atherosclerotic plaque[5-8].Homocysteine (Hcy Homocysteine,) is a sulfur-containing amino acid[9]. In a high levelof Hcy levels is the occurrence and development of Stroke (Stroke) is an important risk factor for[10,11]. At present a large number of literature reports, high plasma levels ofHsCRP, Hcy and ABI decrease and the correlation between atherosclerosis andischemic cerebrovascular disease, but the correlation between HsCRP and Hcy and ABIresearch was limited to patients in the high blood pressure, diabetes and so on, in theacute ischemic cerebrovascular disease research, few reports[12]. Based on this, thisresearch through the acute phase of cerebral infarction patients with ankle arm indexand the correlation of CRP, Hcy is analyzed, in order to investigate whether ABI canserve as a simple means of detection, indirectly reflects the stability of carotid plaques,which provide help for the diagnosis and treatment of acute cerebrovascular disease.Methods：Collected in March,2011-March2013dalian municipal central hospitalneurology treated206cases of the acute phase of cerebral infarction patients, except forinfection and autoimmune disease, record all of the patients age, gender, previous riskfactors (cerebral infarction, diabetes, hypertension, coronary heart disease, atrialfibrillation, smoking, drinking), blood lipids, blood glucose, HsCRP, Hcy, both for ABIdetection, TCD examination, the correlation between ABI and CRP study: divided intonormal CRP group (0mg/l＜CRP≤5mg/l) and CRP abnormal group (CRP>5mg/l); ABI and Hcy correlation studies: divided into Hcy in normal group (0mu mol/l＜Hcy≤10mu mol/l) and Hcy abnormal group (Hcy>10mu mol/l). Applicationsupport SPSS11.5software, and using X2test, t test, logistic regression statisticalmethods to analyze the clinical data, with P <0.05for the difference was statisticallysignificant.Results：1, chi-square test and t test results showed that CRP is normal and abnormal groupin the acute phase of cerebral infarction patients age, hypertension history, diabeteshistory, smoking history, apolipoprotein A1, significant differences of blood sugar, ABI,statistically significant (P <0.05), while sex differences, cerebral infarction, atrialfibrillation, coronary disease, history of drinking, total cholesterol, triglyceride, lowdensity lipoprotein cholesterol (ldl-c), high-density lipoprotein, apolipoprotein B, Hcy,severe stenosis in the main blood vessels, no obvious statistical significance, themulti-factor Logistic stepwise regression equation analysis results showed that age, ABI,independent risk factors for hypertension is abnormal CRP (P <0.05), and diabeteshistory, smoking history, apolipoprotein A1, blood sugar is not independent risk factorsof the CRP disorders (P>0.05). 2, X2test and t test shows: Hcy of normal and abnormal group in acute phase ofcerebral infarction patients gender, age, cerebral infarction medical history, drinkinghistory, significant differences of apolipoprotein A1, statistically significant (P <0.05),and the history of history of hypertension, diabetes, coronary heart disease, atrialfibrillation, medical history, history of smoking, total cholesterol, triglyceride, lowdensity lipoprotein cholesterol (ldl-c), high-density lipoprotein, apolipoprotein B, bloodsugar, HsCRP, ABI, severe stenosis in the main blood vessels, no obvious statisticalsignificance, the multi-factor Logistic stepwise regression equation analysis resultsshowed that age, gender, history of cerebral infarction and alcohol are independent riskfactors for the development of Hcy abnormal (P <0.05), and apolipoprotein A1isabnormal Hcy of independent risk factors (P>0.05).Conclusion：1, age, ABI, hypertension, abnormal CRP in patients with the acute phase ofcerebral infarction is independent risk factor. By measuring the ABI can indirectlyreflect of CRP levels, and then judge the degree of carotid atherosclerosis plaqueinstability, assess the risk of acute ischemic cerebrovascular disease.2, age, gender, history of drinking, history of cerebral infarction and cerebralinfarction in patients with acute stage Hcy abnormal independent risk factor. |
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