The Effect Of Blood Glucose On Patient Undergone Prostate Biopsy

Purpose The first aim of this study was to discuss the impact of blood glucose ofprostate biopsy patients on detection rate of prostate cancer and Gleason score. The secondaim was to evaluate the correlation between blood glucose and Gleason score、tPSA、BMI、TPV and age in patients with prostate biopsy.Methods We prospectively collected the blood glucose, prostate specific antigen,Gleason score, total prostate volume, body mass index, age and other clinical data of452patients who underwent prostate biopsy first time from February2010to April2013in thefirst affiliated hospital of Soochow University. All patients were divided into two groupsby the concentration of6.1mmol/L of blood glucose, the chi-square test was used toevaluate the differences of the detection rate of prostate cancer and Gleason score betweenthe hyperglycemia and the normal blood glucose groups. The correlations between theblood glucose, Gleason score, tPSA, BMI, TPV and age in patients with prostate biopsywere evaluated by the Spearman’correlation analysis.Results There were183prostate cancer patients in452prostate biopsy patients. Thedetection rate of prostate cancer was43.00%and39.77%between the hyperglycemia andthe normal blood glucose groups, respectively, with no statistically significant difference.However, the low Gleason score patients (Gleason score＜7) was20.93%inhyperglycemia prostate cancer patients, significantly higher than the6.43%of the normalblood glucose ones（P＜0.05）.The odds ratio(OR) for the low Gleason score was3.85（95%CI：1.42-10.40）in hyperglycemia prostate cancer patients, while the OR for the highGleason score was0.26(95%CI：0.10-0.70）. The Spearmans correlation analysisdemonstrated that blood glucose negatively correlated with Gleason score(r=-0.256，P＜ 0.05), positively correlated with BMI(r=0.267, P＜0.05), while the correlation with age,TPV, tPSA and I-PSS score has no statistical significance（P＞0.05）.Conclusions The blood glucose had no statistically significant effect on the detectionrate of prostate cancer in patients with prostate biopsy. However, the OR for the lowGleason score was much higher than the OR for the high Gleason score amonghyperglycemia prostate cancer patients. Blood glucose might be used as an independentfactor influencing on Gleason score of prostate cancer in patients with prostate biopsy.