| Objective:To explore the effect on prostatic volume (PV) via the successful control of blood glucose, blood pressure and blood lipids in elderly patients with type 2 diabetes mellitus (T2DM), and then discuss the relationship between blood glucose, blood pressure, blood lipids and benign prostatic hyperplasia (BPH).Methods:T2DM patients were randomly selected from June 2013 to June 2014 at the Department of Geriatrics, Qilu Hospital of Shandong University hospital, a total of 122 cases. All these patients aged 60-89 years and the average age was 71.88±9.38 years. The patients with prostate cancer, urinary tract infection, urethral stricture severe hepatic and renal dysfunction and a pervious history of prostate or transurethral surgery were excluded from the study. The patients were divided into control group and BPH group according to whether they were suffering from benign prostatic hyperplasia. Conforming to the integrated control requirements of the blood glucose, blood pressure, blood lipid on the Chinese type 2 diabetes Prevention Guide (2013), the patients with T2DM were divided into qualified blood glucose group and unqualified blood glucose group, qualified blood pressure group and unqualified blood pressure group, qualified blood lipid group and unqualified blood lipid group. Each group was compared with related indicators of the prostate volume (PV), total prostate specific antigen (T-PSA), free prostate specific antigen (F-PSA), international prostate symptom score (IPSS), quality of life (QOL). Questionnaire survey was conducted for each patient, including IPSS, QOL. Height, weight, waist circumference (WC), blood pressure (BP), pulse pressure (PP), triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fasting blood glucose (FBG), glycosylated hemoglobin (HbAlc), T-PSA and F-PSA were detected and recorded, then the body mass index (BMI) was calculated. Prostate volume (PV) was measured by abdominal ultrasound. All statistical analysis were carried out by SPSS 17.0. Data between different groups were presented as x±s. T test was used in the comparison of different groups. The correlation between variables was analyzed by Pearson correlation analysis.Results:1. The general data between control group (n=56,72.38±9.34 years old) and BPH group (n=66,72.38±9.34 years old) were compared, and there was no significant age difference between the two groups. Compared with control group, WC, BMI, FBG, HbAlc, SBP, PP, TC and LDL-C of BPH group were significantly increased, while HDL-C was significantly reduced (P< 0.05). There was no significant difference of DBP and TG (P> 0.05).2. PV, T-PSA and F-PSA in the qualified blood glucose group were significantly less than unqualified blood glucose group (P< 0.01), while IPSS and QOL were lower in unqualified blood glucose group (P< 0.05).3. Compared with unqualified blood pressure group, PV, T-PSA, F-PSA, IPSS and QOL were significantly reduced in the qualified blood pressure group, differences between the two groups were statistically significant (P< 0.01).4. PV in LDL-C qualified group was significantly reduced, compared with unqualified LDL-C group (P< 0.01). T-PSA was lower than unqualified LDL-C group (P< 0.05). There were no differences of F-PSA, IPSS and QOL between the two groups (P> 0.05). PV, T-PSA, F-PSA, IPSS and QOL in the patients with qualified HDL-C group were significantly reduced by contrast with unqualified group (P< 0.01). PV, T-PSA, F-PSA, IPSS and QOL between the qualified TG group and unqualified were not significant (P> 0.05). PV, T-PSA, F-PSA, IPSS and QOL between the qualified TC group and unqualified were not significant (P> 0.05).5. PV, T-PSA, F-PSA, IPSS and QOL in the patients with qualified blood glucose and blood pressure were significantly reduced by contrast with unqualified blood glucose or/and unqualified blood pressure groups (P< 0.01).6. PV and T-PSA in the patients with qualified blood glucose and LDL-C group were significantly decreased (P< 0.01), while F-PSA, IPSS and QOL significantly reduced (P< 0.05) by contrast with the unqualified blood glucose or/and unqualified LDL-C groups.7. PV, T-PSA, F-PSA, IPSS and QOL were lower in patients whose blood glucose, blood pressure and serum LDL-C were simultaneously qualified compared with unqualified groups(P< 0.01).8. The prostate volume was positively correlated with age, WC, BMI, SBP, PP, FBG, HbAlc, TC, LDL-C, T-PSA, F-PSA, IPSS and QOL, negatively correlated with HDL-C, and no correlation with TG or DBP.Conclusion:1. PV in blood glucose, blood pressure and blood lipid qualified groups was significantly reduced by contrast with unqualified groups in the elderly T2DM patients. Good control of the blood glucose, blood pressure and blood lipid level can delay the progress of BPH.2.Age, obesity, high blood glucose, high blood pressure and high blood lipid ar e risk factors for the elderly T2DM patients with BPH. |
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