Effects Of Exercise-induced Weight Loss On Improvements Of Renal Function In Young Obese Adults

Objective: In the global spread of obesity, obesity is increasing more and more indeveloped countries, obesity rates for children and teenager in China is close to that ofthe developed countries. Obesity has not been ignored, which is not only theindependent risk factor for kidney, also can cause certain damage to renal functionthrough causing by hypertension and dyslipidemia etc. At present the increasingresearch on obesity in kidney, but the influence of weight loss in obese patients’ renalfunction is very few. In this study compared with body form, blood biochemical index,serum creatinine (SCr), creatinine clearance (CrCl) and the change of glomerularfiltration rate (GFR) in obese adolescents of different gender before and after theintervention, body form, sugar, lipid metabolism and changes in renal functionindexes after exercise intervention were explored, for providing certain theoretical andpractical basis on prevention and improvement for obese adolescents.Subjects and methods: A total of26young obese adolescents（14men, mean age20.43±2.85years old;12women, mean age20.36±3.13years old） from Jia Yi MeiLTD in Jiangxi province were selected as the research subject, and23healthy andnormal weight youth as control group. Before experiment, on the basis of health statusand physical fitness status, exercise intensity was determined, individual exerciseprescription and3-month fully-closed nutrition and exercise-induced weight lossinterventions were formulated. Respectively on body shape indexes (height, weight,BMI, waist circumference, hip circumference, body fat rate, etc.), blood biochemicalindicators (fasting blood glucose, blood lipid, insulin, FFA, hs-CRP), blood pressureand renal function indexes (SCr and UA) before and after the intervention weremeasured and detected.Results:1. Before invention female and male subjects body weight, BMI, percent of body fat, waist circumference and hip circumference were significantly higher than in normal weight group (P <0.01). After3-month aerobic exercise intervention, male and female obese youth body weight, BMI, waist circumference, hip circumference and PBF decreased significantly (P<0.01);2. Aerobic exercise can significantly improve blood biochemical indicators for obese youth, male and female obese subjects after intervention, fasting glucose, TC, FINS, H OMA IR, hs-CRP and LDL–C dropped significantly (P <0.01);3. Comparedwith normal weight group, blood pressure was significantly higher before exercise intervention (P <0.01), after aerobic exercise, male and female obese youthSBP and DBP is also significantly reduced (P <0.01);4. After exercise, changes in renal function indexes for obese adolescents: male and female SUA were significantly lowered(P <0.01), SCr for male adolescents decreased very significantly (P<0.01), female subjects decreased but not significantly (P>0.05); CrCl reduced not obviously for male obese subjects(P>0.05), while women decreased significantly (P<0.01); eGFR and SC-GFR increased significantly for maleobese subjects (P <0.01), but the value for female is slightly higher, but no statistical significance (P>0.05).Conclusions:1. Aerobic exercise can significantly reduce youth obesity’s weight,body percent of body fat, WHR systolic blood pressure, diastolic blood pressure,improve centre obesity and have makeable effect on decline of systemic circulationpressure, intra-abdominal pressure of central obesity and lipid renal damage2.Exercise weight loss can significantly improve the fasting blood glucose, blood lipidindex, FINS and inflammatory factor (hs-CRP) to prevent and reduce the risk ofobesity and kidney disease and promote health of obese youth with great significance.3. SUA significantly reduced and eGFR improved in obese adults when significantweight loss, which suggest that early control and prevention of obesity related tokidney disease is of great importance4. Exercise-induced weight loss can producebeneficial effects on blood pressure, blood glucose, lipid and FINS, and inflammationfactor and GFR, which plays a protective role in obese subjects.