Expression Of SPARC, P53, VEGF Protein And Their Clinical Significance In Brain Glioma

PurposeTo investigate the expression of secreted protein acidic and rich in cysteine (SPARC), P53 and VEGF in brain glioma and tumor adjacent brain tissues, and to explore their correlation and clinicopathological singnificance, and after further discussing the three proteins in glioma genesis, the relations between the development.MethodsThe immunohistochemical method was used to detect the expression of SPARC, P53 and VEGF in 90 cases of different pathological grading of gliomas and 90 cases of tumor adjacent brain tissues.Results1. The positive expression rates of VEGF, P53 were significantly higher in brain gliomas than in tumor adjacent brain tissues, respectively(VEGF:75.56% vs 20.00%, P53:68.89% vs 0, P<0.01), but the positive expression rate of SPARC was lower in brain glioma than in tumor adjacent brain tissues(24.44% vs 80.00%, P<0.01).2. The positive expression rate of SPARC and VEGF were associated with histopathology grading in brain glioma (P<0.05); The positive expression rate of P53 was not associated with histopathology grading (P>0.05); VEGF and P53 expression and survival in brain glioma patients had concerned (P<0.05); SPARC expression and survival in brain glioma patients had no concerned (P>0.05).3. In brain glioma tissues, the expression of P53 were positively correlated with the expression of VEGF (rs=0.735, P<0.001);while the expression of SPARC was negatively correlated with the expression of P53 and VEGF, respectively (P53:rs=-0.791, P<0.001 vs VEGF:rs=-0.880, P<0.001).Conclusion1. The expression of SPARC protein was low in gliomas.2. The expression of SPARC、VEGF were closely associated with histopathology grading in brain glioma. It can be used as an auxiliary reference index glioma clinical and pathological grading.3. The expression of VEGF and P53 were closely associated with brain glioma patient survival. The expression of P53, VEGF protein and SPARC showed a certain degree of correlation in brain glioma. Combined detection of SPARC and P53 and VEGF would help prognosis of brain glioma.