Diagnostic And Therapeutic Values Of Immunity Analysis In Ulcerative Colitis Patients

Objective: To study the incidence of UC and T cell subgroup of immune disorders.Methods: According to "Standardize the diagnosis and treatment of inflammatory boweldisease in China consensus opinion"(2012, Guangzhou) diagnostic criteria, we included59patients with UC in active (8remission,51cases) as case group from May2013to May2014in Jilin province people’s hospital. Analyse the general information of the UC patients. Collectperipheral blood samples. By flow cytometry method, to detect the total proportion of T cells(CD3+), CD4+T cells (CD3+, CD4+), CD8+T cells (CD3+, CD8+) ratio, proportion ofCD4+CD25+T cells, B cells (CDl9+and CD3-) and NK cells (CDl6+,56+) ratio.Results:1.In patients with UC group compared to control group in the peripheral bloodlymphocyte subsets of peripheral blood,in patients with UC CD4+T cell ratio is lower thannormal controls (P=0.021), and CD8+T cell percentage higher than that of normal controls(P=0.015), CD25+T cells proportion is higher than normal controls (P=0.034).2. Compared with normal controls, patients with chronic relapse type of CD3+T cellsand CD4+T cells and CD8+T cells and the proportion of CD2+T cells, the difference wasstatistically significant (P <0.05).And the differences between early hairstyle and the controlgroup had no statistical significance (P> o.05).3. The UC patients of type rectum, left neonatal ileoileocolic intussusceptions andneonatal ileoileocolic intussusceptions, compared with normal controls, the proportion ofCD4+T cells and CD8+T cells, CD4+CD25+T cells and NK cells is differences between thefour groups was statistically significant (P <0.05). Further comparison type rectum betweencontrol group, there was no statistical difference (P>0.05), and left neonatal ileoileocolicintussusceptions and the differences between neonatal ileoileocolic intussusceptions have nostatistical significance (P>0.05).4. Remission patients of peripheral blood lymphocyte subsets compared with control group; there was no significant difference (P>0.05).5. There were18cases of UC patients who were from activity to remission aftertreatment. Follow-up found that CD4+T cells and CD8+T cell ratio which before and aftertreatment comparison difference was statistically significant (P <0.05).Conclusions:1. The immune level of UC patients are lower than the control group; the immune levelof chronic recurrent group is lower than the control group; immune level of paracmasis grouphad no significant differences compare to the control group.2.The first episode type of T lymphocyte subsets in patients with UC distribution and thenormal control group has no difference, along with the progression of chronic relapse typeabnormal distribution of T lymphocyte subsets in patients with UC.3. T lymphocyte subsets distribution of remission in patients with UC and the normalcontrol group has no significant difference4. Abnormal distribution of T lymphocyte subsets of patients with UC by positive returnsto normal after treatment.