The Clinical Observation Of Tong Yang,removing Dampness, Eliminating Phlegm And Dispellingstasis Treatment To( Spleen Deficiency And Phlegm- Damp Type) Non- Alcoholic Fatty Liver Disease

BackgroundNon-alcoholic fatty liver disease(NAFLD) refers to a clinical syndrome which is characterized by fatty degeneration and lipid accumulation of liver cells,but it is unrelated to a history of excessive alcohol consumption. It consists of non-alcoholic simple fatty liver, non-alcoholic steatohepatitis, hepatic cirrhosis and cancer associated. NASH, as an important pathologic stage of Nonalcoholic fatty liver disease progression, initiates the process of hepatic fibrosis and cirrhosis. Although people use a variety of modern technology to delve into the disease,they still failed to clarify the etiology and pathological mechanism of the disease. At present, there is no specific treatment to the disease, polyene phosphatidyl choline-based comprehensive treatment is applied in the world.In amending liver function, blood lipid, etc.There is certain curative effect by traditional Chinese medical treatment, but It is hard to reach the purpose by the single treatment.According to the principle that fatty liver tissue produce more eactive oxygen species(ROS),which activates hepatic macrophages to release cytokines promoting the liver inflammation such as Interleukin 1(IL- Interleukin- 1, IL-1), Tumor necrosis factor(Tumor necrosis factor, TNF). Combined with the nuclear pathogenesis of the disease:phlegm dampness and blood stasis, We use Wuling powder and Eliminating phlegm stasis fang(fritillary bulb,uniflower swisscentaury root,salviae miltiorrhizae) along with polyene phosphatidyl choline to treat the 39 NASH patients of spleen deficiency phlegm wet type. ObjectiveTo investigate the clinical efficacy of Tong Yang,removing dampness,eliminating phlegm and dispelling stasis method in treating NASH. MethodThe subjects of the study were seventy-eight NASH patients of spleen deficiency and phlegm-damp type who were admitted to our outpatient clinic and hospitalization from July 2012 to July 2013(BMI > 24kg/ ㎡).These patients were randomly divided into control group(n=39)and experimental group(n=39).The former was given a single oral administration therapy of polyene phosphatidyl choline,while the latter took polyene phosphatidyl choline combined with the corresponding TCM treatment of wuling power and eliminating phlegm stasis fang for 3 months.Observe the two groups of patients’ Improved Conditions by clinical symptoms, body mass index, liver function, blood lipids and ultrasound imaging. Use ’’ t’’ test and chi-square by SPSS16.0 software system to analyse the data collected above. ResultAfter three months’ standard treatment,observation group total efficient is 87.18%,while the contrast group is 66.67%.The total effective rate of observe group was significantly higher than that in control group(P<0.05).Wuling power and eliminating phlegm stasis fang is effective in improving ALT,GGT,blood lipids,body mass index and clinical symptoms(p < 0.05). ConclusionAn emphasis on Tong Yang, removing dampness,eliminating phlegm and dispelling stasis treatment is one of the effective clinical choice for the NASH patients of spleen deficiency and phlegm-damp type.