Clinical Analysis Of Cranial Venous Sinus Abnormalities In Patients With Central Nervous System Infection

Objective The aim of the clinical study was to observe the results of the anatomy and the anomaly of the cranial venous sinus by examining the brains of patients suffering from the central venous system infection with MRI(magnetic resonance imaging) and MRV(magnetic resonance venography),thus to explore the correlation between the central nervous system infection and the cranial venous sinus anomaly.Methods The subjects in this study are selected from the Neurology Department of Cardia-cerebrovascular Disease Hospital Affiliated to Ningxia Medical University from September, 2011 to September, 2014. There are 45 cases of patients with central nervous system infection confirmed and 46 cases of patients without central nervous system infection. They are labeled the case group and the control group. All the patients will receive the MRI and MRV on their brains, so that the anatomy and the anomaly of the cranial venous sinus will be observed.SPSS 17.0statistical software was applied to analyze the results.Results 1. Comparison of the anomaly rate of MRV results between the ICNS group and the control group: There are 35 cases of MRV anomaly in the ICNS group, with the anomaly rate of 77.8%, while there are 34 cases of MRV anomaly in the control group, with the anomaly rate of 73.9%. Thus, χ2=0.185,P=0.667>0.05, indicating that there is no statistical significance of the MRV anomaly between the two groups.2. Comparison of the occurrence rate of CVST between the ICNS group and the control group: There are 9 cases of cranial venous sinus thrombosis in the ICNS group, with the occurrence rate of 20.0%, while no case is found in the control group, with the occurrence rate of 0.0%. It is obvious that the occurrence rate of CVST in the ICNS group is much higher than that in the control group. P=0.001<0.05, indicating that there is a statistical significance.3. Comparison of the parts of the anatomical structural variation of each venous sinus between the ICNS group and the control group: There are 7 parts of anatomical structural variation of the superior sagittal sinus in the ICNS group, while there are 6 parts in the control group. There is only one part of the anatomical structural variation of the inferior sagittal sinus in the ICNS group, while there are 3 parts in the control group. There are 17 parts of the anatomical structural variation of the left transverse sinus in the ICNS group, while there are 16 parts in the control group. There are 10 parts of the anatomical structural variation of the right transverse sinus in the ICNS group, while there are 11 parts in the control group. There are 15 parts of the anatomical structural variation of the left sigmoid sinus in the ICNS group, while there are 14 parts in the control group. There are 6 parts of the anatomical structural variation of the right sigmoid sinus in the ICNS group, while there are 10 parts in the control group. There are 2 parts of the anatomical structural variation of the straight sinus, while there are 3 parts in the control group. By comparing the different parts of the anatomical structural variation of the venous sinus: In the superior sagittal sinus, χ2=0.117 and P=0.732. In the inferior sagittal sinus, χ2=1.001 and P=0.617. In the left transverse sinus, χ2=0.088 and P=0.766. In the right transverse sinus, χ2=0.037 and P=0.848. in the left sigmoid sinus, χ2=0.088 and P=0.767. In the right sigmoid sinus, χ2=1.109 and P=0.292. In the straight sinus, χ2=0.189 and P=1.000. Therefore, no statistical significance has been found between the two groups.Conclusion 1. No significant correlation has been found between the infectious disease of the central nervous system and the cranial venous sinus anomaly, while the central nervous system infection is correlated with the cranial venous sinus thrombosis. The most common part where venous sinus thrombosis forms is the superior sagittal sinus, and the next part is the transverse sinus.2. No significant correlation has been found between the infectious disease attack of the central nervous system and the anatomical structure of the cranial venous sinus. As for the patient suffering from the central nervous system infection, the greatest feature of the anatomical structure of the cranial venous sinus is the variability of the transverse sinus, which conforms to the feature of the structural variation of the cranial venous sinus of people that does not suffer from the central nervous system infection.