The Relationship Between Helicobacter Pylori Eradication And Curative Effect Of Gastroesophageal Reflux Disease

OBJECTIVE:To investigate the relationship between Hp eradication and curative effect of gastroesophageal reflux disease(GERD).METHODS:Two hundred and fifty four patients with GERD were prospectively recruited for endoscope and acid reflux evaluation.according to the results of gastroscope,The eligible patients were divided into non-erosive reflux disease (NERD) and erosive esophagitis (EE) group,and each divided into Hp positive and Hp negative group, the Hp positive group were randomly divided into the anti Hp treatment group and not.These patients were assigned to rabeprazole triple therapy(the anti Hp treatment group) or rabeprazole(20mg, twice per day) single(other groups) for ten days,Then rabeprazole (20mg,twice per day) was given to all patients until two months.Then all patients underwent acid reflux evaluation, EE group underwent endoscopy,and all patients underwent a 13C urea breath test 4 weeks after cessation of rabeprazole to determine Hp status.RESULTS:One hundred and seventy nine GERD patients were included in the study(NERD group 119 cases, including anti Hp group 47 cases, not anti Hp group 32 cases, Hp negative group 40 cases; EE group 60 cases, including anti Hp group 24 cases, not anti Hp group 15 cases, Hp negative group 21 cases).Hp was eradicated in 76.6% of the NERD anti Hp group and in 75% of the EE anti Hp group.Overall,there is no difference between the anti Hp group and other groups on these aspects,including symptom、esophagitis and acid reflux improvement.CONCLUSION:There are no significant correlation between Hp eradication and GERD.