| Objective:This paper systematically discusses the pathogenesis of bronchial asthma, reviewes the theory of prevention and treatment of combination of traditional Chinese and Western Medicine by treating bronchial asthma. That "sputum" is considered to be an important part of traditional Chinese medicine. Qinyi compound is the summary of clinical experience of Longdi Liu Professor, who works in Nanjing University of Traditional Chinese Medicine, in treating bronchial asthma. This prescription is according to the mechanism of prescription in eliminating wind and phlegm, relieve asthma by lower qi. Many previous experimental study confirmed that Qinyi compound can inhibit airway inflammation in asthmatic guinea pigs. This study intends to further explore the mechanism through clinical research, and to observe its combined with western medicine applied in clinical, compared with western medicine alone in shortening the course of treatment, improve the efficacy of the advantages.Methods:Collect 65 patients, clinical stage of mild and moderate bronchial asthma, TCM syndrome type of wind phlegm syndrome, were randomly divided into observation group (Qinyi compound combined with basic treatment (Budesonide and formoterol Fumarate Powder for Inhalation (160ug/4.5ug/60 ceiling), one ceiling, twice a day. In patients with mild or moderate, if asthma not relieved, up to 6 ceiling/ day; when condition stable, can reduce, at least to 1 ceiling/day; if exacerbations, intravenous injection of theophylline or antibiotics)) 33 cases and control group (basic treatment only) 32 cases. By comparing the clinical and laboratory indications before and after treatment between observation group and control group (such as blood eosinophil (Eos), exhaled nitric oxide (FeNO), pulmonary function test (FEV1, FEV/FVC), TCM syndrome, asthma control test score (ACT)), evaluate the clinical effects of the two regimens.Results:(1)the total effective rate of observation group and the control group were 90% and 80%,but the difference between the two groups was not significant (P> 0.05). (2) In terms of symptoms and signs of Chinese Medicine, the cough symptoms in the observation group were significantly lighter than those in the control group (P< 0.05); In addition, the other Chinese symptoms of the two groups were alleviated, but the difference was not big (P> 0.05); (3) As for the improvement time of asthma, wheezing, shortness of breath, cough, expectoration, the observation group was significantly shorter than the control group (P< 0.05);(4) As for Eos, FEV1, FEV1/FVC and FeNO, the two groups were better after treatment than before treatment. And the observation group comparing with the control group, there was a significant difference (P< 0.05); (5) As for ACT, the two groups were better after treatment than before treatment. And the observation group comparing with the control group, there was a significant difference (P< 0.05). (6) The assessment of the blood and urine routine, liver and kidney function, ECG before and after the treatment showed no obvious abnormalities. There was no side effects.Conclusion:(1) Qinyi compound combined with basic treatmen is more able to relieve cough in patients with mild and moderate asthma. And the symptoms (asthma, wheezing, shortness of breath, cough, expectoration) improvement time was significantly shorter than that of basic treatment; (2)Observation group was better than control group in the improvement of Eos, FeNO and lung function, ACT scores. Qinyi compound with basic treatment was better than control group on asthma control. (3)There was no adverse reaction in two groups, Qinyi compound was recommended for clinical use. |
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