| Background:Gastroesophageal reflux disease refers to the gastric contents into esophageal discomfort symptoms and (or) complications of a disease, the disease is common disease in the western countries, and the incidence is rising trend year by year. Recent epidemiological studies have shown that the disease prevalence in China is about 5%. Along with our country economic development brought about by the lifestyle changes, and the problem of aging population increased incidence of a disease. GERD has become a worthy medical problems in our country. In this paper, we study designed of the treatment of GERD liver stomach muggy syndrome of traditional Chinese medicine clinical effect, the standard of the unified GERD in TCM diagnosis and treatment for the future reference.Objective:To observe open depressive and stomach in the treatment of GERD liver stomach muggy syndrome clinical efficacy, to explore the correlation of GERD and mental psychological factors, to evaluate the effect of disease and treatment on patients’quality of life.Methods:Use prospective cases analysis, observation during February 2015 to January 2015, from the first affiliated hospital of guangzhou university of TCM clinic, aged 18 to 70 years, liver stomach muggy syndrome patients diagnosed with GERD. Through into the group after the screening, after screening the depressive and stomach party primary party (atractylodes, poria cocos, pseudostellaria root, bitter orange, cuttlebone, big belly skin, calcined ocher, corrugated, rhizoma coptidis, evodia rutaecarpa, caulis perllae, zhejiang fritillary bulb), clinical in the add and subtract:Those with modern disorder, can add radix bupleuri, radix paeoniae alba; Those upset, can add scutellaria, gardenia, dandelion; Belching, can add agilawood, radix aucklandiae; Those with chest distress and chest pain can add salvia miltiorrhiza, snakegourd fruit peel; Those painful, can add rhizoma cyperi, rhizoma corydalis; Those with constipation, can add rhubarb, fructus aurantii immaturus; Those with foreign body sensation in pharynx, can add dried tangerine or orange peel, pinellia and magnolia bark; The person that weigh of damp and hot, add bamboo shavings, stone calamus; Insomnia, can add calcined magnets, flos albiziae. Participants included five observation indexes, including in patients with depression and the stomach before the treatment, Chinese medicine treatment of the fourth week, Chinese medicine treatment of 8 weeks of gastroesophageal reflux disease questionnaire total score, Zung’s self rating anxiety scale (SAS) score, Zung’s depression self rating scale (SDS) score. This article statistics data by paired t test and rank and inspection methods are analyzed.Results:55 patients with GERD liver stomach muggy syndrome observation are completed.1.GerdQ scores change rank and inspection analysis many depressive and stomach a depressive and stomach before the treatment, Chinese medicine treatment of the fourth week, Chinese medicine treatment of 8 weeks GerdQ scores, with the questionnaire score less than eight points defined as no obvious reverse flow, heartburn symptoms or symptoms improved significantly earlier. After SPSS statistical analysis, the results suggest that depressive and stomach open depressive and stomach before the treatment, Chinese medicine treatment of the fourth week, Chinese medicine treatment for 8 weeks GerdQ< 8 percentage points respectively 0%,49.1%,78.2%, and the results have differences, statistically significant difference(P<0.001, P<0.05).2. TCM symptom classification of quantitative table score changesPaired t test and rank and inspection method, this paper analyses the scale scores, the primary symptom integral, integral result. TCM symptom classifying quantization table total score changes:open depressive and stomach (16.96±4.58) before treatment, treatment of the fourth week (13.89 ±4.47), Chinese medicine treatment for 8 weeks (11.13±4.17), the treatment of each time node score has the difference, the difference was statistically significant (P< 0.001, P< 0.05). Compared with before treatment,4 weeks treatment of dry and bitter mouth, constipation symptoms did not see obvious difference; 8 weeks and 4 weeks treatment, irritability, constipation symptoms did not see obvious difference, the rest of symptom integral are difference between point, and the difference is statistically significant (P< 0.05). Before and 4 weeks treatment,4 weeks and 8 weeks of treatment the mean difference is respectively:3.07,2.86, compare before and 4 weeks treatment the average difference is the largest.3. Clinical efficacy evaluation of traditional Chinese medicine of the spleen and stomach esophagus stomach module of PRO scale score system diseasePaired t test and rank and inspection, this paper analyses the scale total score, four areas, eight aspects of grading results. Open the depressive and stomach before treatment for (52.42±16.36), Chinese medicine treatment of the fourth week (46.79±15.56), Chinese medicine treatment for 8 weeks (42.07 ±14.78), the point score have differences, the differences were statistically significant (P< 0.001, P< 0.05), including depression and stomach before treatment with Chinese medicine treatment of the fourth week, Chinese medicine treatment of the fourth week, and the average difference between the traditional Chinese medicine treatment for 8 weeks, respectively,5.63,4.72, open depressive and stomach treatment with Chinese medicine treatment of the fourth week before comparing the mean difference is the largest. Four areas score change results in various fields of each point score changes by the test analysis, the results have differences, the differences were statistically significant (P< 0.001, P< 0.05). PRO scale in the result of changes in every aspect on the change of each time node has the difference was statistically significant (P< 0.05).Conclusion:1. Open depressive and harmonize the stomach decoction in the treatment of gastroesophageal reflux disease of liver in patients with gastric muggy syndrome main symptoms such as reflux, heartburn, often pain, belching, etc is of great significance. The total curative effect of Traditional Chinese medicine treatment of 4 weeks, treatment of 8 weeks is respectively:12.7%, 76.4%.2. For this study, only a small number of gastroesophageal reflux disease patients are accompanied by anxiety and depression symptoms, therefore, curative effect is not statistically significant.3. Open depressive and harmonize the stomach decoction can improve the quality of the survival in the treatment of gastroesophageal reflux disease. |
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