Synthesis Of New N-Heterocyclic Carbenepalladium Complexes And Their Applications Toward Carbon-Nitrogen And Carbon-Carbon Bond Formation

Transition-metal palladium catalyzed reactions of aryl chlorides and ?-arylation of ketones are important methods to build C-N and C-C bond.1)A new type of N-heterocyclic carbene-Pd Cl2-?iso?quinoline complexes was successfully achieved in acceptable to good yields from easily available starting materials under mild conditions,and their structures were unambiguously confirmed by X-ray single crystal diffraction.Furthermore,their catalytic activity toward Buchwald-Hartwig arylamination of aryl chlorides with primary and secondary amines was fully tested.Under the optimal reaction conditions,the expected arylated amines can be obtained in high to excellent yields at low catalyst loadings?0.005-0.05 mol%?.2)From easily available starting materials,another type of novel and well-defined N-heterocyclic carbene-palladium?II?-7,8-benzoquinoline complexes was developed and their structures were fully confirmed by X-ray single crystal diffraction,¹H and ¹³C NMR,MS,elemental analysis and IR.In addition,initial studies on their catalytic properties showed that they were efficient catalysts in the Buchwald-Hartwig amination and ?-arylation of ketones using aryl chlorides as the arylating reagents.