| Objective: Carotid atherosclerosis is a common cause of ischemic cerebrovascular disease,cerebral infarction occupies a large proportion in ischemic cerebrovascular disease,the incidence rate increased year by year,and becomes a serious threat to people’s life and health.This study aims to explore the correlation between homocysteine and cerebral infarction and the formation of carotid artery plaque,and verifies whether it is a risk factor for cerebral infarction and whether there is correlation between homocysteine and the formation of carotid artery plaque in cerebral infarction patients,therefore,to seek the theoretical basis for the prevention and treatment of cerebral infarction and the formation of carotid artery plaque.Methods: Select 120 hospitalized cases with acute cerebral infarction within 48 hours onset from the Department of Neurology,the Great Wall Hospital of Shijiazhuang City from December 2014 to December 2015 as the case group,and select contemporaneous 70 cases of the physical examination in hospital as the control group.Then divided the case group into 3 subgroups according to the results of carotid ultrasonography,they are cerebral infarction group A(stable plaques),cerebral infarction group B(vulnerable plaques)and cerebral infarction group C(no plaque),and the cerebral infarction group A along with cerebral infarction group B are the group of plaque,cerebral infarction group C is the group without plaque.It required that there are no statistical significance(P>0.05)between the control group and the case group,and between the group of plaque and the group without plaque in terms of age,gender.This study focused on the following researches:(1)the Hcy level differences between the case group and the control group.(2)the Hcy level differences between the group of plaque and the group without plaque.(3)the Hcy level differences between cerebral infarction group A and cerebral infarction group B.(4)Logistic regression analysis on the risk factors of cerebral infarction and the formation of carotid artery plaque,which includes age,gender,systolic blood pressure,fasting glucose,low-density lipoprotein cholesterol,triglycerides,uric acid.(5)the correlation between Hcy and traditional risk factors.Result:1 HCY,SBP,GLU of the case group were significantly higher than those of the control group(P<0.01);TC,TG,LDL-C,SUA was higher than that in the control group(P<0.05);HDL-C were lower than those of the control group(P<0.05);there was no significant difference(P>0.05)of Apo-A1,Apo-B between the case group and the control group.2 HCY,LDL-C,GLU of the group of plaque were significantly higher than those of the group without plaque(P<0.01);TC,TG,SBP was higher than that of the group without plaque(P<0.05);HDL-C were lower than those of the group without plaque(P<0.05);there was no significant difference(P>0.05)of SUA,Apo-B,Apo-A1 between the group of plaque and the group without plaque.3 HCY of cerebral infarction group B was significantly higher than that of cerebral infarction group A.4 Multivariate logistic regression analysis showed that HCY is an influence factor in cerebral infarction(OR=1.17,95% CI 1.11~1.25,P<0.05),and also an influence factor in the formation of carotid artery plaque of the patients with cerebral infarction(OR=4.67,95% CI 1.23~17.79,P<0.05).5 Hypertension,hyperglycemia,dyslipidemia,smoking and alcohol can lead to the increasing of HCY level.Conclusion:In addition to the traditional risk factors,high HCY hyperlipidemia is also a risk factor of cerebral infarction and the formation of carotid artery plaque.The increasing level of HCY can reflect the property of carotid artery plaque indirectly.The higher the HCY level,the worse the stability of carotid artery plaque.Many factors can affect the level of HCY. |
