Observation Of Curative Effect Of Combined Using Of Nfrared Irradiation And Recombinant Human Epidermal Growth Factor On Surface Chronic Ulcer

Purpose: The skin,the organ directly contacting with the outside world over human body surface,protect the body tissues and organs from outside force,chemical,and pathogenic microorganism,and maintain the stability of the human body environment.It is also one of the largest organs in the body.Because lots of factors from external can lead to damage to the skin,the skin normal function would be impaired and form a wound.According to the length of the healing time after damage,wounds can be divided into two kinds,acute wounds and chronic wounds.Acute wounds generally refer to wounds within 2 weeks.Chronic wounds generally refer to the wounds for more than 2 weeks due to some factors which can hinder the healing of the wound,such as infection,effusion,huge wounds,foreign bodies,and so on.Generally speaking,chronic wounds which were not incurable directly may be infected secondary with granulation tissue growth and ulcers.The floorboard of the infrared ray is a kind of broadband electromagnetic that can go through the human body skin to promote blood circulation,reduce local exudation,and promote wound healing.Infrared ray therapy is very common in clinical treatment because it is economical and convenient,and it is especially suitable for primary hospital.Epidermal growth factor is a kind of polypeptide growth factor.It can be combined with a specific cell surface receptors,activate the membrane receptor cells within the period of tyrosine protein kinase phosphorylation,leading to a series of biochemical reactions like protein C activation G and phosphatases,and promote wound healing through increased DNA synthesis and cell proliferation.The aim of this study is the treatment efficiency of chronic ulcer through the infrared irradiation and recombinant human epidermal growth factor methods to guide further clinical treatment.Methods: Cases were collected without other factors affecting wound heal,such as diabetes,peripheral vascular disease,chronic wasting disease,etc.To exclude the impact on healing of wound area,collect cases whose wound areas ranged from 10 cm2 to 16 cm2 to make sure the cases can be accurately compared.According to the visit order,we divided all the cases into 6 groups:group1(conventional treatment group),group2(infrared irradiation),group3(recombinant human epidermal growth factor solution),group4(recombinant human epidermal growth factor gel),group5(infrared + recombinant human epidermal growth factor solution treatment group),group 6(infrared + recombinant human epidermal growth factor gel treatment group).Wounds were treated by removing necrotic tissue and seepage and saline rinse.Group 1: the sulfadiazine silver cream was smeared evenly on the wound with the thickness of about 1 mm,and eight thick gauze were covered on the wound,tape fixed dressings.Group2: wounds were treated with infrared radiation 2 times a day,20 minutes at a time.Group3: the recombinant human epidermal growth factor solution was sprayed evenly on the wound,8 gauze were covered on the wound with a thick layer,tape fixed dressings.Group4: the recombinant human epidermal growth factor gel was smeared evenly on the wound with the thickness of about 1 mm,and eight thick gauze were covered on the wound,taped by fixed dressings.Group5: treated with infrared radiation,2 times a day,20 minutes at a time.Group6: besides the treatment of group4,treated with infrared radiation,2 times a day,20 minutes at a time.According to the date of treatment,the rate of wound healing was calculated respectively on day 3,7,11,15.5.3 record all wound healing time.Wound healing were covered by the epithelial cells as the ultimate healing the finish.All the calculated the wound healing rates were statistically studied using SPSS13.0 software,that is,analyzing whether difference exists among curative effects of different treatments.Data information used to (?)±s,group comparison between the SNK-q inspection,inspection level for alpha = 0.05.Results:A total of 84 wounds of 72 cases were studied including 42 male cases and 30 female cases with mean age of 42.2 ±7.3 years old(28-72).45 wounds were caused by trauma,13 cases were secondary to surgery,26 were pressure ulcers;6 wounds were located on upper limb,16 on abdomen,32 were on hips and 18 small wounds were on the back,while 12 were on the lower limb.1 Healing time of each group.Healing time of using infrared irradiation + epidermal growth factor is shorter,and healing time in routine treatment was the longest,and other healing time had no significant difference.Because of different size of wounds,further comparison between groups were needed.2 Wound healing rate in each group.Healing rate on the time of 3 days is almost the same between each group,and the healing rate of conventional treatment group was obviously lower than other groups.The healing rate of infrared + recombinant human epidermal growth factor gel of treatment group was obviously higher than that of other groups;the healing rate of recombinant human epidermal growth factor gel treatment group is higher than that of the solution treatment group;the healing rate of infrared irradiation treatment group and that of infrared + recombinant human epidermal growth factor was similar.Conclusion:1 The infrared radiation and recombinant human epidermal growth factor can effectively promote wound healing.2 The effect of recombinant human epidermal growth factor gel solvent treatment is better than that of recombinant human epidermal growth factor.3 The effect of combination of infrared irradiation and recombinant human epidermal growth factor gel was better than that of single treatment.