Significance Of Galectin-3、CK19 And MC In Different Risk Stratification System Of Papillary Thyroid Microcarcinoma

Objective: To study the prevalence of galectin-3,ck19 and mc in postoperative histological specimens and evaluate the association between the expression intensity of Galectin-3,CK19 and MC which were prognostic factors of PTMC. The prognostic factors of PTMC included age,tumor size,multifocality,extrathyroidal extension, lymph node metastasis and risk stratification.Methods: Between January 2015 and December 2015, 250 consecutive PTMCs which had underwent surgery and the analysis of galectin-3,ck19 and mc were enrolled. Total thyroidectomy or hemithyroidectomy with routine central neck dissection were performed. Lateral neck node dissection were performed when suspicious lesions were detected in preoperative imaging or during the surgical procedure.To evaluate the relationship between prognostic factors including age,tumor size,multifocality,extrathyroidal extension, lymph node metastasis,risk stratification and the expression intensity of Galectin-3,CK19,MC by the χ2 test. All statistical analyses were performed using statistical software(SPSS, version 20.0).Results: Of the 250 PTMCs, 244(97.6%),249(99.6%),236(93.6%) cases respectively had posivive Galectin-3,CK19,MC in postoperative histological specimens. Galectin-3,ck19 expression had no significant association with prognostic factors such as age,tumor size,multifocality,extrathyroidal extension, lymph node metastasis and risk stratification in conventional PTMC. There was significant difference between the expression intensity of MC and risk stratification of PTMC.Along with the higher risk stratification goes a higher expression intensity of MC.Conclusions: Postopreative MC analysis using postoperative specimens may be useful to predict the prognosis of consecutive PTMCs. Postoperative Galectin-3,CK19 analysis using postoperative histological specimens maybe not advisable in patients with conventional PTMC.