Effects And Expression Of Survivin And Aurora-b In Laryngeal Carcinoma

Objective: This study aimed to investigate Survivin and Aurora-b expression in laryngeal carcinoma and to determine the possibility of Survivin and Aurora-b being a biomarker in laryngeal carcinoma diagnosis or being an predictor of overall survival(OS)in laryngeal carcinoma patients underwent surgical resection.Methods: Survivin and Aurora-b were determined in 86 cases of laryngeal carcinoma,86 cases of adjacent tissues of cancer and 22 cases of normal tissues by immunohistochemistry(IHC).Results: The expression levels of Survivin and Aurora-b were significantly higher in laryngeal carcinoma than that in adjacent tissues of laryngeal and normal tissues(P <0.01).The expression level of Survivin had positive relevance to the tumor-node-metastasis and recurrence in laryngeal carcinoma(P <0.05);The expression level of Aurora-b had positive relevance to the pathological grade clinical stag(TNM stage)and recurrence in laryngeal carcinoma(P <0.05);Survival curves show the expression levels of Survivin and Aurora-b in laryngeal cancer is associated with prognosis of laryngeal carcinoma.the result of COX regression analysis: the expression of Aurora-b and recurrence are independent prognostic risk factors for postoperative patients with laryngeal carcinoma(P <0.05),but not for the expression of Survivin and lymph node metastasis.Conclusions: Our study shows Survivin,Aurora-b and their interaction might be part of the metastasis and prognosis of laryngeal carcinoma.The expression levels of Survivin and Aurora-b might be biomarkers for laryngeal carcinoma diagnosis and an independent predictor of OS after surgical resection,which would provide a novel insight into diagnosis and therapy of laryngeal carcinoma.