Risk Factors Associated With Hyperuricemia In Type 2 Diabetes Mellitus And TCM Syndrome Research

Purpose:Through a retrospective study of in type 2 diabetes mellitus with hyperuricemia,this thesis analyzes its relationship with the blood glucose,blood lipid,liver function,renal function,obesity and risk factors that causing diseases,discusses the distribution of TCM syndrome,and understands the relationship between various clinical factors correlated with hyperuricemia in patients with type 2 diabetes mellitus and traditional Chinese medicine the syndrome,in order to provide a more comprehensive clinical prevention and treatment of the disease.Material and method:Collecting 193 cases of T2 DM patients hospitalized in the Department of endocrinology of the Affiliated Hospital of Liaoning traditional Chinese medicinebetween January 2015 and December 2016;conducting a retrospective study on two classified groups---group HUA and group NO-HUA according to whether hyperuricemia exists or not;discussing the relationship between related index and the T2 DM with HUA and analyzing of the distribution of TCM syndrome according to the standards of TCM.Results: 1.There was no statistical difference between the two groups,so they were comparable.The index difference of age,weight,BMI,waist circumference,systolic blood pressure,diastolic blood pressure,fasting C peptide,2 hour postprandial C peptide,triglyceride,high density lipoprotein cholesterol,GGT,AST,alt,serum creatinine,urea,creatinine clearance rate and other indicators had statistical significance(P < 0.05).The index difference of fasting blood glucose,glycosylated hemoglobin,total cholesterol,low density lipoprotein cholesterol had no statistical significance(P > 0.05).UA is positively correlate with body weight,WC,DBP,TG,CRE and CCR,negatively correlate with age and HDL-C.Logistic regression analysis show that body weight and CRE are risk factors for T2 DM combine with HUA.2.Two groups of syndromes: group HUA(48.8%): Yin deficiency,Yang deficiency and Qi deficiency(26.8%)(52.4%)(67.1%),blood stasis and phlegm damp syndrome(58.5%),damp heat syndrome of spleen qi deficiency(40.2%),(37.8%);group NO-HUA(70.6%): Yin deficiency and yang deficiency(18.8%)(52.9%),Qi deficiency and blood stasis syndrome(49.4%),phlegm(27.1%),damp heat syndrome of spleen qi deficiency(11.8%),(25.9%).3.The distribution of syndromes between the two groups: Yin deficiency syndrome,blood stasis syndrome,phlegm dampness syndrome,and damp heat syndrome had different statistical results(P < 0.05);Yang deficiency syndrome,Qi deficiency syndrome,and spleen qi deficiency syndrome had no statistical difference(P> 0.05).Conclusion: 1 Age,weight,BMI,waist circumference,systolic blood pressure,diastolic blood pressure,fasting C peptide,2 hour postprandial C peptide,triglyceride,high density lipoprotein cholesterol,GGT,AST,alt,serum creatinine,urea,and creatinine clearance are related to the incidence of T2 DM with HUA,body weight and CRE are dangerous factors for T2 DM combine with HUA,and surmising that TG in no significant renal impairment of T2 DM combine with HUA population is not a risk factor.2.The main syndrome of T2 DM combined with HUA is Qi deficiency and blood stasis,complicated with yin deficiency syndrome and phlegm dampness syndrome.3 the main factors affecting the occurrence and development of T2 DM combined with HUA are phlegm dampness syndrome,damp heat syndrome and blood stasis syndrome.