MOFs-[Nd₃?D-cam?₈?H₂O?₄Cl]_n Stationary Phase In HPLC

Chiral metal-organic frameworks?MOFs?because of its porous,stable,selectively modifiable feature,are widely used as HPLC stationary phase.However,MOFs have some disadvantages such as their non-uniform particle size and irregular shape.Therefore,there is a great challenge for the preparation of stationary phase of metal-organic frameworks.The main work of this thesis is as follows:A MOFs material[Nd₃?D-cam?₈?H₂O?₄Cl]_n was synthesized,which was used as the stationary phase for the separation of chiral compounds.According to the experimentalresults,the[Nd₃?D-cam?₈?H₂O?₄Cl]_ncolumnandthe[Nd₃?D-cam?₈?H₂O?₄Cl]_n-silica gel column could separate six and nine pair enantiomers,respectively.Two different interfacial polymerization methods were used to immobilize the[Nd₃?D-cam?₈?H₂O?₄Cl]_n on silica gel.The separation of 18 or 13 kinds of chiral racemates could be reached by the immobilization of interfacial polymerization of piperazine and trimesoyl chloride,or m-phenylenediamine and trimesoyl chloride.This method is more effective than above pure crystal and pure crystal-silica gel stationary phase.We studied the polyether sulfone immobilized[Nd₃?D-cam?₈?H₂O?₄Cl]_n as a stationary phase.The results showed that 12 kinds of chiral compounds were able to be separated.