| Objective To investigate the effect of chorioamnionitis on physical and neurological development in infancy of premature infants of gestational age less than 34 weeks.Methods 1?From January 2014 to June 2016,78 cases of preterm infants less than 34 weeks were followed up to 12 months to correct the 12 months of hospitalization at the Qingdao women's and children's hospital.According to the placental pathology,there were no chorioamnionitis,divided into group CA(group A)41 premature infants,non CA group(group B)37 cases of preterm infants.33 mature healthy infants(group C)who were randomly selected in the department of child health care.Analysis and compare the differences neural motor development in their infancy.2?Follow up time: preterm infants were followed up for 1 months in the first 6 months of corrected age,after that age followed up 1 times every 2-3 months.If abnormal condition was found during the period,adjusted the follow-up time properly.3?Follow up content: 1)Physical assessment: head circumference,length and weight.2)Neuromotor development:in the correction of the age of 6 and 12 months old,compele Bayley tests,include,mental development index(MDI)? psycomotor development index(PDI)and compele 20 neuromotor tests.4?Diagnostic criteria: 1)Growth retardation:Head circumference and body length and weight less than or equal to the age of the gender growth standard tenth percentile(?P10),reference growth criteria for Chinese children's growth standard and growth curve.2)Bayley infant development test grading standard:MDI < 70 was divided into mental retardation,and PDI < 70 was psycomotor retardation.3)20 abnormal neuromotor examination:in accordance with the infant 20 neuro motorial examination standard,each divided into normal and abnormal two,found more than 2 abnormal items for screening abnormal.Results 1?Comparison of physical development: 1)The growth retardation rate of premature infants in group CA was 1,2,3,6 and 12 month old,respectively 43.90%?36.6%?26.8%?19.5%?12.2%;The preterm infants in the non CA group were respectively 35.1%?29.7%?24.3%?13.5%?10.8%,there is no statistical significance in the difference(P> 0.05).2)When Group CA preterm and non CA premature infants corrected the age to 1,2,3,6 and 12 month old,compare their head circumference and body length and body weight,there is no statistical significance in the difference(P> 0.05).3)At the corrected age of 6 months,the length and weight development of the two groups of preterm infants were lower than those of the mature healthy infants Group,and the difference was statistically significant(P < 0.05).4)At the corrected age of 12 months,the growth of premature infants in non CA group was lower than that of the mature healthy infants group,and the difference was statistically significant(P < 0.05).The physical development of preterm infants in group CA was compared with that of non CA group and mature infant group,the difference was not statistically significant(P > 0.05).2?Comparison of neuromotor development: 1)At the corrected age of 6 months,the scores of MDI and PDI in preterm infants in group CA were lower than those of non CA premature infants and full-term infants group,the difference was statistically significant(P < 0.05).2)At the corrected age of 12 months,there was no significant difference in the scores of MDI and PDI between the three groups(P > 0.05).3)At the corrected age of 6?12 months,The abnormal rate of 20 neuromotor examination in two groups of preterm infants was higher than that in the mature healthy infants group,and the difference was statistically significant(P < 0.05).There was no significant difference between the two groups of preterm infants(P > 0.05).Conclusion Premature infants of gestational age less than 34 weeks with chorioamnionitis are more likely develop physical and mental retardation in infancy. |
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