The Clinical Research Of Combining ShuhejiangNi Decoction With Pantoprazole In The Treatment Of Non-erosive Reflux Disease With Syndrome Of Liver Qi Invading Stomach

Objective:To observe the clinical efficacy,safety of Non-erosive Reflux Disease with syndrome of liver qi invading stomach by combining ShuHeJiang-Ni Decoction with Pantoprazole.Simultaneously aim to explore a new train of t-hought on integrated traditional Chinese and Western Medicine treatment of N-on-erosive Reflux Disease.Method:we included 154 patients with Non-erosive Reflux Disease,divided into treatment group and control group randomly(77 cases in the treatment group and 77 in the control one).The treatment group combine ShuHeJiangNi decoction with Pantoprazole enteric capsule,the control one use Pantoprazole enteric capsule separately,the Course of treatment was 4 weeks.Then,observe the remission Degree,quality of life and adverse reactions of main symptoms and concomitant symptoms of TCM in the two group individually in pretherapy,treat for 2 weeks and post-treatment,including the recurrence of withdrawal for 4 weeks and 8 weeks.In addition,statistical analysis by using SPSS 21.0 statistical software,contrasting the short-term and long-term clinical efficacy,relapse rate,and medicinal safety.Results:1.The total effective rate of the clinical main symptoms of the treatment group was higher than that of the control one(P<0.05),which was 90.91%,84.42%respectively.2.The total score of the main symptoms of the two groups was significantly reduced(P<0.01),the reduction in the treatment group was greater than that in the control one(?P<0.01).3.The main symptoms of treatment group were significantly improved after 2 weeks of treatment(P<0.01),Food regurgitat had no obvious remission in the control group(P>0.05),the remaining symptoms were improved significantly(P<0.01);The improvement of acid reflux,heartburn and retrosternal pain in the treatment group were better than those of the control one(?P<0.05or0.01),acid reflux,heartburn showed more obvious(?P<0.01),there was no difference in the improvement of food regurgitat between them(?P>0.05);4.The main symptoms of treatment group were significantly improved after 4 weeks of treatment(P<0.01),Food regurgitat had no obvious remission in the control group(P>0.05),the remaining symptoms were improved significantly(P<0.01);After treating for 4 weeks,the main symptoms of the treatment group were better than those of the control one(P<0.01 or 0.05),heartburn and Retrosternal pain improved more obvious(P<0.01);5.The total score of the TCM symptoms of the two groups was significantly reduced(P<0.01),the reduction in the treatment group was greater than that in the control one(?P<0.01).6.The concomitant TCM symptoms of the treatment group were improved obviously after 2 weeks of treatment(P<0.01),being improved after 4 weeks(P<0.01or0.05),Dull pain in the chest and diaphragm,Hypochondriac pain and poor defecation had no obvious improvement in the control group(P>0.05),Upset irritability had no obvious improvement than 2 weeks before(P>0.05),Hypochondriac pain had no obvious improvement than pretreat(P>0.05),the remaining symptoms were improved(?P<0.01or0.05),putrid belching and acid swallowing,heartburn,epigastric fullness,anorexia,dry mouth and bitter taste,nausea and vomiting and poor defecation in the treatment group were better than those of the control one after 2 weeks,4 weeks of treatment(?P<0.05),epigastric fullness,anorexia,dry mouth and bitter taste,upset irritability improved more obvious(?P<0.01),the improvement of TCM symptoms in the treatment group was significantly better than that in the control one after 4weeks(P?0.01).7.The total effective rate of TCM symptoms of the treatment group was significantly higher than that of the control one(P<0.01),which was97.40%,75.32% respectively.8.The recurrence rate of withdrawal for 4 weeks and 8weeks of the treatment group was 5.71%,8.57% respectively,the control one was21.54%,27.69%,the former was lower than the latter(P<0.05),the difference in withdrawal for 8 weeks showed more significant between them(P<0.01).9.No obvious side effects and adverse events were observed during the course of treatment.Conclusion:The therapy of combining ShuHeJiangNi Decoction withPantoprazole has advantage in improving the clinical main symptoms and and the the accompanying TCM symptoms of NERD patients with syndrome of liver qi invading stomach than using Pantoprazole alone,in addition,can reducing relapse rate,improving the long-term efficacy and safety,being worthy of further clinical researchand promoting the application.