Association Between Serum Lipid And Colorectal Polyps

?Objective?This study was designed to compare the differences of serum lipid and lipoprotein between patients with colorectal polyps and healthy controls,which aimed to evaluate the correlation of lipidemia with the development of colorectal polyps.? Methods ? One hundred and twenty-one patients with colorectal polyps and forty-eight healthy volunteers were included in the study.Serum lipid and lipoprotein were measured by an enzymatic assay.The colorectal polyps were classified based on the pathological characteristics.There were four types of colorectal polyps in this study: hyperplastic polyp(HP),tubular adenoma(TA),tubulovillous adenoma(TVA)and the adenoma with high-grade dysplasia(A-HGD).The patients could be divided into the groups with or without advanced adenoma according to the number,size and histological type of colorectal lesions.?Results? Low density lipoprotein cholesterol(LDL-C)level was significantly higher in patients with different histological lesions than health control group(p=0.014).The LDL-C values increased significantly whether or not the polyps were larger than 10mm(p<0.05).The LDL-C value for patients with advanced adenoma was higher than that of controls(p=0.002),but the difference was not significant between patients with and without advanced adenoma(p>0.05).The cut-off values of triglyceride(TG)and LDL-C to distinguish the patients with polyps from healthy controls was 0.96 mmol/L(AUC=0.604,p=0.035)and 3.02 mmol/L(AUC=0.666,p=0.001).Obesity,age,higher levels of TG and LDL-C were the independent risk factors for the formation of colorectal polyps.?Conclusions?Colorectal polyps were more easily to be found in obesity and older patients.There was correlation between elevated serum level of LDL-C and the development of colorectal polyps,especially the advanced adenoma.LDL-C was less sensitive than TG in in terms of distinguishing patients with polyps from healthy controls,elevated LDL-C had less sensitive but higher specificity than TG.