Clinical Study On The Relationship Between Serum Vitamin A,Vitamin D And Vitamin E Levels In Common Childhood Diseases

Background:Vitamin A,vitamin D and vitamin E are fat-soluble vitamins;The main physiological role of vitamin A is to maintain vision,maintain the health of epithelial cells,promote the synthesis of mununoglobulin's,maintain normal bone growth and growth and promote growth reproduction;The main physiological role of vitamin D is to regulate the body's calcium and phosphorus metabolism and bone development;The main physiological role of vitamin E is a strong antioxidant,anti-aging,maintaining human endocrine and reproductive system function plays an important role.This topic is a phenomenon observed in the study of other related topics of vitamin A,vitamin D and vitamin E,and has been clinically analyzed.Purpose:This study aims to understand the relationship between vitamin A,vitamin D and vitamin E and common childhood diseases,in order to provide a basis for the supplementation of vitamin A,vitamin D and vitamin E in sick children.Method:A retrospective analysis of some children who were admitted to the pediatrics department of the Third Affiliated Hospital of Xinxiang Medical College from 2017 to 2018,1129 of them were given serum vitamin A test,of which 262 were given serum vitamin D test,of which 1224 were given serum.Vitamin E test;this collection of statistics on the age,gender,clinical diagnosis of the disease and serum vitamin A,serum vitamin D,serum vitamin E test results.The method for detecting serum vitamin A,vitamin D and vitamin E is by high performance liquid chromatography(HPLC).Results:In our study,serum vitamin A levels were measured in 1129 children.The age ranged from 0 to 18 years old.There was a significant difference in serum vitamin A levels between different age groups(F=4.530,P=0.0014).The younger the serum vitamin A level is the lower;however,there were no significant difference in serum vitamin A levels between boys and girls.253 cases of the 1129 children in this group had pneumonia at the same time;155 of the 253 children with pneumonia had vitamin A deficiency at the same time,the incidence of vitamin A deficiency was 61.27%,and the serum vitamin A deficiency rate was at all ages there were also significant differences between the groups.The younger the age,the higher the vitamin A deficiency rate(x 2=20.124,P=0.0005);145 cases of the 1129 children in this group had repeated respiratory infection;48case of the 145 children with repeated respiratory infections had vitamin A deficiency,and the incidence of vitamin A deficiency was 33.10%,but there was no significant difference in serum vitamin A deficiency among all age groups(?2=2.6894,P=0.6111);48 cases of the 1129 patients in this group were also obesity;there was a significant difference in serum vitamin A levels among the 48 obesity children(F=8.461,P=0.0001).Serum vitamin D levels were detected in 262 patients,aged 0-18 years,and serum vitamin D levels were significantly different in different age groups(F=24.83,P<0.0001);however,serum vitamin D levels were not significant differences between boys and girls(t=0.6875,P=0.4924).Of the 262 cases,79 cases had pneumonia at the same time;the 79 patients with pneumonia had serum vitamin D levels below 50?g/L,67 of which also had vitamin D deficiency,but the incidence of vitamin D deficiency in each group was in all age groups there was no significant difference(?2=4.5133,P=0.2111);Of the 262 cases,25 cases had repeated respiratory infections;the serum vitamin D levels of the 25 children with repeated respiratory infections were less than 50 ?g/L;the serum vitamin D levels of the 25 children with repeated respiratory infections were also significantly different.(F=5.393,P=0.0065);however,the incidence of vitamin D deficiency in the 25 patients with repeated respiratory infections was not significantly different in all age groups(?2=5.5903,P=0.1334).In our study,1224 cases were tested for serum vitamin E content,of which 245 cases had pneumonia at the same time;The serum vitamin E level of the 245 children with pneumonia was lower than 0.8 mg/L;And the serum vitamin E levels of each age group were significantly different(F=3.242,P=0.0129);13 of the 245 children with pneumonia also had vitamin E deficiency,but there was no significant difference in the incidence of vitamin E deficiency in each group(?2=7.5274,P=0.1105).Conclusion:Serum vitamin A,vitamin D and vitamin E in children with different degrees of disease are reduced to varying degrees.It is necessary to timely supplement vitamin A,vitamin D and vitamin E in children with diseases.