Correlation Between Serum Vitamin A Level And Pneumonia In Infants

Pneumonia is one of the most common childhood diseases,a serious threat to children's health,and a mental and economic burden on families and society.Therefore,the prevention and treatment of this disease is particularly important.Vitamin A(VA)is an important micronutrient in human body,which can form photosensitive substances,affect epithelial stability and integrity,and maintain and enhance immune function.Vitamin A deficiency disorder(VAD)is A common public health nutrition problem,among which subclinical vitamin A deficiency and suspected subclinical vitamin A deficiency have no specific manifestations,mainly causing respiratory tract infection,diarrhea and other effects.Infants and young children grow quickly,have high nutritional needs,and are more prone to vitamin A deficiency,which increases the morbidity and mortality of infectious diseases.This study focused on the correlation between serum vitamin A levels and pneumonia in infants and their severity.Objective:To explore the relationship between serum vitamin A level and pneumonia and its severity in infants,and to provide A theoretical basis for evaluating the severity of pneumonia in infants with vitamin A in the treatment of pneumonia.Methods:A total of 115 cases of infantile pneumonia treated in the outpatient department of pediatric medicine and inpatient department of the affiliated hospital of cheng De medical college from December 2017 to December 2018 were selected as the observation group,which were divided into mild case group and severe case group according to the severity of the disease.In the observation group,there were 68 boys and 47 girls,aged from 28 days to 3 years,with an average age of 15.80±10.50 months.During the same period,115 healthy infants and young children in the outpatient department of children's health care in our hospital were randomly selected as the control group,including 65 males and 50 females,aged from 28 d to 3 years,with an average age of 16.57±10.2 months.The VA levels of the two groups were measured on an empty stomach the following morning.According to the VA level,they were divided into SVAD group,SSVAD group and normal group.The relationship between infantile pneumonia and serum vitamin A level was analyzed by means of t-test and chi-square test.Results:1.There were no statistically significant differences in age and gender between the observation group and the control group(t=0.539,P=0.590,t=0.160,P=0.689),indicating comparability.The VA level in the observation group was lower in the infant group than in the infant group,and the difference was statistically significant(t=3.218,P=0.001).2.The serum VA level of the observation group(0.25± 0.10 mg /L)and the serum vitamin A level of the control group(0.31± 0.09 mg /L)was significantly lower than that of the control group(t=4.744,P < 0.001).The incidence of VAD between the two groups was higher in the observation group(72.04%)than in the control group(47.82%),with a statistically significant difference(X2=15.292,P=0.000).3.The VA level of the severe group(0.22±0.10 mg/L)was lower than that of the mild group(0.27±0.10 mg/L),with statistically significant difference(t=3.044,P < 0.05).There were 28 cases(51.82%,28/54)of SVAD in the severe group,and 20 cases(32.78%,20/61)of SVAD in the mild group.The incidence of SVAD in the severe group was higher than that in the mild group,with a statistically significant difference(X2=4.281,P< 0.05).However,there was no significant difference in the rate of suspected subclinical vitamin A deficiency between the two groups(X2=0.194,P > 0.05).Conclusion:1.The VA level of infants with pneumonia was significantly lower than that of normal infants of the same age,and the VA level was negatively correlated with the occurrence of infants with pneumonia.2.The severe group had lower VA level and higher incidence of VAD.The VA level was negatively correlated with the severity of pneumonia in infants.