| Objective:To analyze the relationship between the different pathological grades of phlegm syndrome of type 2 diabetes mellitus and relationship with related physical and chemical indicators,as well as the syndrome elements and miscellaneous time,in order to further understand the pathogenic role of sputum in T2 DM,so as to provide objective basis for clinical treatment based on syndrome differentiation of T2 DM,slow down or block the occurrence and development of T2 DM and its complications,and provide reference for its from a microscopic perspective.Methods:T2DM patients in the outpatient and inpatient department of endocrinolo gy of people’s hospital affiliated to fujian university of traditional Chinese medicine fr om February 2018 to October 2018 were collected.The data collected included four d iagnostic information and general information,at the same time,blood samples were c ollected and their blood routine,fasting blood glucose,glycosylated hemoglobin,2-h p ostprandial blood glucose,total cholesterol,triglycerides,high-density lipoprotein,low-d ensity lipoprotein,apolipoprotein A1,apolipoprotein B,ApoB/ApoA1 and other indicat ors were tested.The method of syndrome element differentiation was used to different iate and extract syndrome elements,according to phlegm syndrome element integral,200 patients with T2 DM were divided into groups.When the phlegm score was less th an 70,it was group A(no pathological changes),A total of 43 cases.The phlegm sc ore of 70 sputum <100 was group B(mild pathological change),a total of 54 cases.The phlegm score of 100 sputum <150 was group C(moderate pathological change),a total of 53 cases.When the phlegm score integral 150,group D(severe pathologica l changes),a total of 50 cases.The clinical data were sorted out and statistically anal yzed using SPSS24.0.Results:1.Comparing T2 DM phlegm syndrome in patients with different pathological grade s of general data,the results showed that gender,WC,BMI,eating habits,systolic bl ood pressure difference was statistically significant(P<0.05),WC and BMI of group D were significantly higher than those of groups A,B and C(P<0.01),and systolic blood pressure of group C and D was significantly higher than that of group A and B(P<0.01),and phlegm syndrome different pathological grade and gender,WC,BMI,ea ting habits,systolic blood pressure were positive correlation(P<0.05),the correlation co efficient were 0.171,0.375,0.470,0.283,0.243.2.In T2 DM patients,phlegm syndromes with different pathological grades were m ainly located in the kidney,liver,spleen,gallbladder,channels and collaterals.Syndro me elements of solid diseases were mainly concentrated in dampness,heat,blood stasi s,qi stagnation and dryness.Syndrome elements of deficiency diseases were mainly c oncentrated in Yin deficiency,qi deficiency,Yang deficiency and blood deficiency.Co mparison between groups characteristic of disease,illness prompts the liver,spleen,we t,heat,and qi stagnation,blood stasis,qi deficiency,Yang deficiency group difference was statistically significant(P<0.05);Compare groups in pairs,the liver in group D w as higher than group A,B,C group was higher than group A,spleen disease in grou p D was higher than A,B,C three groups,group C higher than that of group A,B,wet disease of B,C,D group were higher than in group A,C,D group was higher than group B,C and D in the fever group were higher than in group A,and qi sta gnation and blood stasis disease of D group were higher than in group A,B,C,Yan g deficiency disease in group D was higher than group B,In qi-deficiency,group D was higher than group A,B and C(P<0.05);and phlegm syndrome with different pat hological grade of liver,spleen,dampness,heat,and qi stagnation and blood stasis,qi deficiency,Yang deficiency were positive correlation(P<0.05),the correlation coefficie nt were 1.000,1.000,0.881,0.870,1.000,1.000,1.000,0.922.3.Comparing T2 DM phlegm syndrome in patients with different pathological grade s of glycosylated hemoglobin,fasting plasma glucose,postprandial 2 hours blood gluc ose,blood lipid and apolipoprotein,results show that the glycosylated hemoglobin,fast ing blood glucose,blood sugar 2 hours after meal differences had no statistical signifi cance(P>0.05),the TC,TG,LDL-C,ApoB,ApoB/ApoA1 ratio,number of chronic co mplications difference was statistically significant(P<0.01);compare groups in pairs,T C and LDL-C in group D were significantly higher than those in group A and B,TG in group C and D were significantly higher than those in group A,ApoB and ApoB/ApoA1 in apolipoprotein C and D were significantly higher than those in group A,a nd chronic complications in group B,C and D were significantly higher than those in group A(P<0.01);different pathological grades of phlegm syndrome were positively correlated with TC,TG,LDL-C,ApoB,ApoB/ApoA1 ratio,and the number of chroni c complications(P<0.05),with correlation coefficients of 0.338,0.316,0.299,0.412,0.390,0.501.4.Patients with T2 DM with different pathological grades of phlegm syndrome wer e divided into five groups: wet,hot,qi stagnation,blood stasis and dryness.In the w et group,there were statistically significant differences in age,WC,BMI,TC,LDL-C,ApoB,ApoB/ApoA1 ratio,dietary habits and gender(P<0.01).WC,BMI,TC,ApoB and ApoB/ApoA1 of group D were higher than those of group A and B,In the conc urrent heat group,WC,BMI,TC,TG,LDL-C,ApoB,ApoB/ApoA1 were significantly different(P<0.01),WC,BMI,TC,ApoB and ApoB/ApoA1 of group D were higher t han those of group A and B;In the concurrent qi stagnation group,WC,BMI,TC,ApoB,ApoB/ApoA1 and dietary habits were significantly different(P<0.01),BMI of gro up D were higher than those of group A,B and C;In the group with blood stasis,WC,BMI,dietary habits,LDL-C and ApoB were significantly different(P<0.01),WC,BMI,LDL-C and ApoB of group D were higher than that of group A;WC,BMI an d HbA1 c were significantly different in the concurrent drying group(P<0.01).5.Patients with T2 DM whose phlegm syndromes included Yin deficiency,Yang de ficiency,qi deficiency and blood deficiency in different pathological grades were divid ed into different groups.In the group with Yin deficiency,WC,BMI,dietary habits,TC,TG,LDL-C,ApoB,ApoB/ApoA1 were significantly different(P<0.01),WC,BMI,TC,TG,LDL-C,ApoB and ApoB/ApoA1 in group D were higher than those in grou p A and B;WC,BMI,TG,ApoB,ApoB/ApoA1 were significantly different in the co ncurrent Yang deficiency group(P<0.01),WC,BMI of group D were higher than thos e of group A,B and C;WC,BMI,dietary habits,TC,LDL-C,ApoB and ApoB/Apo A1 in the group with qi deficiency were statistically significant(P<0.01),WC and BMI of group D were higher than those of groups A,B and C(P<0.05).In the concurre nt blood deficiency group,there were statistically significant differences in BMI,gender,TG,LDL-C,ApoB and ApoB/ApoA1(P<0.01),BMI of group D were higher than t hose of groups A,B and C(P<0.05).6.According to the different pathological grades of phlegm syndrome and the othe r mixed distribution of pathogenic syndromes,there was a significant positive correlati on between dampness,heat,qi stagnation,blood stasis,qi deficiency and Yang deficie ncy(P<0.05),with correlation coefficients of 0.881,0.870,1.000,1.000,0.922 and 1.000,respectively.Conclusion:1.In T2 DM patients,BMI,WC,dietary habits and blood pressure are closely relat ed to different pathological grades of phlegm syndrome,it is suggested that the treatm ent of phlegm may improve the body weight,WC and blood pressure of patients with diabetes,and at the same time show the importance of adjusting diet.2.In T2 DM patients,liver,spleen,dampness,heat,qi stagnation,blood stasis,qi d eficiency and Yang deficiency are closely related to different pathological grades of p hlegm syndrome;In clinical treatment,the pathogenicity of phlegm should be attached importance to,reasonable expectorant to prevent diabetes and its complications.3.TC,TG,LDL-C,ApoB and ApoB/ApoA1 have guiding significance and referen ce value for the early diagnosis and intervention of phlegm syndrome of type 2 diabet es.4.In T2 DM patients,phlegm syndrome element is easily mixed with dampness,he at,qi stagnation,blood stasis,Yang deficiency and qi deficiency syndrome element,w hich has a great influence on blood lipid,apolipoprotein and BMI,and phlegm may b e the dominant factor. |
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