| Objective:Recurrent abdominal pain(RAP)is a common clinical symptom in pediatrics,which indicates that the duration of abdominal pain is more than 3 months,with more than 3 episodes.It is more common in children aged 3 years or above,and the incidence rate in girls is higher than in boys,which is a common reason for children's repeated visits.RAP has many causes.In recent years,it has been found that Helicobacter pylori(H.pylori)infection is closely related to the incidence of RAP.In this study,13C-Urea Breath Test(13C-BUT),hemotyping detection of H.pylori and gastroscopy were performed on children with RAP to explore the incidence of H.pylori infection in children with RAP,and the correlation between the type of H.pylori and the severity of abdominal pain.Methods:From February 2017 to August 2018,210 children were admitted to the inpatient and outpatient department of pediatrics of binzhou medical college affiliated hospital for RAP were randomly selected,including 81 boys and 129 girls,aged 4-12 years,with an average age of(8.2±3.5)years,improving 13C-UBT.In addition,select 152 cases of H.pylori positive children as experimental group,the boy 58 cases,94 cases of the girls,ages 4 to 12 years old,the average age was(8.0±3.6),improve the H.pylori serotyping detection:I type,II type,middle type;In the normal control group,110 healthy children were selected from the physical examination center during the same period,including 48 boys and 62 girls,aged from 5 to 12 years old,with an average age of(8.3±3.0)years old,improving 13C-UBT The positive rates of H.pylori in the RAP group and the control group were recorded as P1 and P2,respectively.The children in the two groups were comparable in age and gender,and the difference was not statistically significant(P>0.05).The experimental group recorded the values in the 13C-UBT report sheet corresponding to each type of H.pylori,and analyzed the differences.Experimental group with gastroscope inspectors,a total of 125 patients,according to the degree of gastric mucosal lesions under gastroscope is divided into:mild inflammation group,moderate inflammation group,severe inflammation group and normal gastric mucosa group,gastritis classification with reference to the Sydney classification.The correlation between the blood clearance classification of H.pylori and the degree of gastric mucosal lesions was analyzed,and the relationship between 13C-UBT value and the degree of gastric mucosal lesions.Results:(1)The infection rate of H.pylori in the RAP group was higher than that in the healthy control group(72.38%vs 40.0%),and the difference was statistically significant(?2=31.89,P<0.01),that is,P1>P2.(2)13C-UBT numerical value of different H.pylori serotyping is as follows:type I of H.pylori:16.59 ± 1.264;Type ? of H.pylori:10.55 ± 2.139;Intermediate H.pylori 10.62±3.148.13C-UBT value of type I H.pylori is higher than type II H.pylori and middle type H.pylori.And the differences were statistically significant(t=18.86,P<0.01;t=13.85,P<0.01);13C-UBT numerical value in ? type of H.pylori and middle type of H.pylori was no statistically significant difference(t=0.12,P>0.05).(3)There is a certain correlation between the H.pylori serotyping and the degree of gastric mucosal inflammation.Type I of H.pylori is associated with severe gastritis with 12 cases,and type ? of H.pylori is associated with severe gastritis with 3 cases,and middle type of H.pylori with severe gastritis with 2 cases.Compared with II type and middle type of H.pylori,differences were statistically significant(?2=7.06,P<0.01;?2=7.77,P<0.01),whereas there was no significant difference between ? type and middle type in severe gastritis(?2=0.02,P>0.05);Type ? of H.pylori is associated with mild gastritis with 24 cases,and middle type of H.pylori with mild gastritis with 18 cases,there was no statistically significant difference in mild gastritis(?2=0.58,P>0.05);Type ? of H.pylori is associated with moderate gastritis with 9 cases,and middle type of H.pylori with moderate gastritis with 10 cases,there was no statistically significant difference in the moderate gastritis(?2=0.32,P>0.05)(4)The value of 13C-UBT was correlated with the degree of gastric mucosal lesions.The value of 13C-UBT in the severe gastritis group was higher than that in the mild,moderate and normal gastric mucosa groups,with statistically significant differences(t=9.79,P<0.01,t=11.02,P<0.01;t=65.54,P<0.01,respectively);The 13C-UBT value in the mild gastritis group was higher than that in the normal gastric mucosa group,and the difference was statistically significant(t=15.70,P<0.01),However,there was no significant difference with the moderate gastritis(t=1.58,P>0.05).Conclusions:(1)The occurrence of child RAP is related to H.pylori infection.(2)There is a certain relationship between the H.pylori serotyping and the value of 13C-UBT.The 13C-UBT value of type I of H.pylori is higher than type II of H.pylori and middle type of H.pylori,but there was no statistical difference between the latter two values,which may be related to the small sample size.(3)The H.pylori serotyping is related to the degree of gastric mucosal inflammation under gastroscopy.The lesion degree of gastric mucosa under gastroscope is heavier in children with type I of H.pylori.(4)According to the statistics,there was a certain correlation between the degree of gastric mucosal lesions under gastroscopy and the value of 13C-UBT. |
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