Clinical Observation Of Dijupingan Capsule In The Treatment Of Hypertensive With Left Ventricular Diastolic Dysfunction

ObjectiveThe purpose of this study was to observe the clinical efficacy and safety of dijupingan capsule in the treatment of left ventricular diastolic dysfunction in hypertension patients with syndrome of yin deficiency and blood stasis,and to provide a theoretical basis for the treatment of this disease with traditional Chinese medicine.MethodsThis study collected 72 patients of hypertension with left heart diastolic dysfunction from Shanxi Provincial Institute of TCM cardiovascular clinic with syndrome of yin deficiency and blood stasis.According to the principle of randomization,the patients were divided into the experimental group and the control group.All of them were given one nifedipine controlled-release tablets at 30 mg once a day for 8 weeks,in addition,the patients of observation group plus 3 pills of dijupingan Capsule each time,3 times a day.The changes of TCM syndrome integral,blood pressure in the consulting room,24-hour ambulatory blood pressure(24h SBP,24 h DBP,d SBP,d DBP,n SBP,n DBP),echocardiography(E,A,E/A)and safety index were measured before and after treatment in the two groups and performed statistical analysis.Results1.A total of 72 cases were included,including 36 cases in the experimental group,1case of shedding,36 cases in the control group,and 4 cases of shedding.Two groups of patients with general information(gender,age,disease course,hypertension grade,classification of hypertension risk),TCM syndrome integral,blood pressure in the consulting room,24-hour ambulatory blood pressure(24 HSBP,24 HDBP,d SBP,d DBP,n SBP,n DBP),echocardiography(E,A,E/A)had no statistics significance(P>0.05).2.Blood pressure in the consulting room: Systolic and diastolic blood pressure levelsof patients in two groups both decreased after treatment,and the difference was statistically significant(P<0.05)compared with before treatment.Compared with the control group,the blood pressure of the observation group decreased significantly,and the difference was statistically significant(P<0.05).3.24-hour ambulatory blood pressure: The dynamic blood pressure indexes(24h SBP,24 h DBP,d SBP,d DBP,n SBP,n DBP)of the two groups were decreased after treatment and the difference was statistically significant(P<0.05)compared with those before the study.The dynamic blood pressure indexs of the observation group was significantly lower than that of the control group,and the difference was statistically significant(P<0.05).4.Echocardiography: Echocardiography indexes(E,A,E/A)of two groups were improved after treatment,and the difference was statistically significant(P < 0.05).The improvement degree of E,A and E/A in the observation group was better than the control group,and the difference was statistically significant(P<0.05).5.TCM syndrome integral and The curative effect: The TCM syndrome integral of two groups were decreased after treatment,and the difference was statistically significant(P<0.05)compared with before treatment.The degree of score decline in the observation group was significantly different from that in the control group(P<0.05).The efficacy of TCM syndromes in the observation group(82.9%)was better than that in the control group(59.4%),and the difference was statistically significant(P < 0.05).6.In this clinical observation,the patients' vital signs were stable,and blood routine examination,urine routine,stool routine,liver and kidney function,blood lipids,blood glucose and electrolytes were no statistically significant(P<0.05)compared with before treatment.In the control group,there were 2 patients with ankle edema due to adverse reactions of nifedipine controlled-release tablets,the patients could tolerate it without affecting the test.ConclusionDijupingan capsule combined with nifedipine controlled-release tablets can improve the clinical symptoms of hypertensive with left ventricular diastolic dysfunction due to syndrome of yin deficiency and blood stasis.In addition to lowering blood pressure,it can also reduce A,improve E,E/A,thus improving left ventricular diastolic function.The effect is better than the control group.