Clinical Study On Shennao Fuyuan Decoction Combined With Acupuncture In The Treatment Of Ischemic Stroke Patients With Kidney Deficiency And Blood Stasis

Objective: To explore the clinical efficacy and safety of the combined treatment of Shennao Fuyuan decoction combined with acupuncture therapy for ischemic stroke with renal deficiency and blood stasis,so that we provide treatment ideas for ischemic stroke.Methods: 90 cases were selected from February 2016 to February 2018 in the First Affiliated Hospital of Hunan University of Chinese Medicine,which were divided into 3groups,with 30 cases in each group.Patients in group A was given the Shennao Fuyuan decoction on the basis of the routine treatment.Patients in group B was given acupuncture treatment on the basis of the routine treatment.Patients in group C was given the Shennao Fuyuan decoction combined with acupuncture on the basis of the routine treatment.All patients were treated continuously for 2 weeks.Record the patients' basic data.The National Institutes of Health Stroke Scale(NIHSS),Activity of Daily Living Scale(ADL),traditional Chinese medicine(TCM)symptom scale,clinical efficacy and hemorheology indexes were observed before treatment and 2 weeks after treatment.The blood routine,urine routine,stool routine,liver function,renal function,myocardial enzymes and electrocardiogram were observed and the adverse reactions were recorded to evaluate the safety of the treatment.Results:1.General information: In this study,the actual effective cases were 30 in three groups.There was no statistically significant difference(p>0.05)of the gender,age,condition,duration,medical history and TCM symptom scale of three groups before treatment,which showed that the three groups were comparable.2.Clinical efficacy: After 2 weeks of treatment,the clinical efficacy of group C was better than that of group A and group B,and the differences were statistically significant(p<0.05).3.NIHSS: After 2 weeks of treatment,the NIHSS scores of the three groups were lower than those before treatment,and the differences were statistically significant(p<0.05).The NIHSS score after treatment in group C was lower than that of group A and group B,and the differences were statistically significant(p<0.05).4.ADL: After 2 weeks of treatment,the ADL scores of the three groups were higher than those before treatment,and the differences were statistically significant(p<0.05).The ADL score after treatment in group C was higher than that of group A and group B,and the differences were statistically significant(p<0.05).5.TCM symptom scale: After 2 weeks of treatment,the TCM symptom scale scores of the three groups were lower than those before treatment,and the differences were statisticallysignificant(p<0.05).The TCM symptom scale score after treatment in group C was lower than that of group A and group B,and the differences were statistically significant(p<0.05).6.Hemorheology indexes: After 2 weeks of treatment,the whole blood low shearing viscosity,whole blood high shearing viscosity,plasma viscosity and fibrinogen after treatment in group C were decreased compared with group A and B,and the differences were statistically significant(p<0.05).The whole blood high shearing viscosity and fibrinogen after treatment in group A and B were decreased compared with those of the same group before treatment,and the differences were statistically significant(p<0.05).The whole blood low shearing viscosity,whole blood high shearing viscosity,plasma viscosity and fibrinogen after treatment in group C were decreased compared with those before treatment,and the differences were statistically significant(p<0.05).7.Safety evaluation: Before and after treatment,there were no obvious abnormal changes in blood routine,stool routine,urine routine,liver function,renal function,myocardial enzyme and electrocardiogram.No obvious adverse reactions were observed during and after treatment.There was no statistically significant difference of ALT,AST,Cr,BUN after treatment in group A,B and C(p>0.05).There was no significant difference before and after treatment in the same group(p>0.05).Conclusion:Shennao Fuyuan decoction combined with acupuncture therapy using in patients with ischemic stroke with renal deficiency and blood stasis can improve the neurological function,the ability of daily living and clinical efficacy,decrease the hemorheology parameters,with good security,which is helpful for clinical promotion.