Association Between Plasma Remnant Cholesterol Levels And Expression Of High Sensitive C-reactive Protein In Patients With Type 2 Diabetes Mellitus

Objective:To investigate the association between plasma remnant cholesterol(RC)levels and expression of high sensitive C-reactive protein(hs-CRP)in patients with type 2 diabetes mellitus(T2DM)by analyzing RC and hs-CRP levels of these patients.Methods:414 T2DM patients who were diagnosed and treated in Affiliated Hospital of North Sichuan Medical College from October 2017 to October 2019 and 100 healthy controls were enrolled.The clinical data of two groups were collected,then the levels of HbAlc and biochemical indexes were detected.And the levels of RC were calculated.RC levels of diabetic group and control group were compared,and then association between RC and T2DM was evaluated by logistic regression analysis.T2DM patients were further divided into quartiles based on RC levels,and the association between RC levels and expression of hs-CRP was analyzed.RC levels of T2DM patients were compared between the two groups according to whether the patients had coronary heart disease or not.Results:1.Plasma levels of RC in T2DM patients were significantly higher than that in control group,and the difference was statistically significant[0.70(0.47,1.04)mmol/L vs 0.45(0.31,0.61)mmol/L,z=-6.959,P=0.000].2.Logistic regression analysis showed that RC was a relevant factor of T2DM(95%CI:1.120～15.560,P=0.033).3.There were statistical differences in hs-CRP levels among RC quartile groups(χ2=23.253,P=0.000),and the hs-CRP levels in the fourth quartile group were significantly higher than that in the first,second and third quartiles groups,and the difference was statistically significant[1.64(0.70,4.24)mg/L vs 0.70(0.13,3.14)mg/L,0.60(0.13,2.08)mg/L,1.23(0.24,3.25)mg/L,z=-3.812,-4.595,-2.164,P<0.05].4.Correlation analysis showed that RC levels and hs-CRP levels were positively correlated(r=0.218,P=0.000).5.Multiple linear regression analysis suggested that there was an independent association between RC levels and expression of hs-CRP(t=2.540,P=0.011).6.Compared with T2DM patients without coronary heart disease,plasma RC levels of patients with coronary heart disease increased significantly,and the difference was statistically significant[0.79(0.54,1.22)mmol/L vs 0.69(0.46,0.98)mmol/L,z=-2.196,P=0.028].Conclusion:1.RC levels of T2DM patients were significantly higher than that of controls.Compared with T2DM patients without coronary heart disease,RC levels of patients with coronary heart disease increased significantly.These findings suggested that RC may be associated with the occurrence and development of T2DM and diabetes cardiovascular complications.2.Compared with the control group,the concentration of hs-CRP in the case group was significantly higher.Hs-CRP levels showed an increasing trend with increase of RC levels,and the two were positively correlated.All above indicated that RC may be related to chronic inflammation in T2DM patients.