Study On Characteristics Of Premature Coronary Heart Disease And Analysis Of TCM Syndrome Types

ObjectiveThis study aims to study the characteristics of premature coronary heart disease and the characteristics of TCM syndrome types,and provide data for TCM prevention and treatment of premature coronary heart disease.MethodsSummarize and sort out 744 clinical cases of patients who were hospitalized with coronary angiography in Cardiovascular Department of Guangdong Hospital of Traditional Chinese Medicine Main Hospital and Fangcun Hospital.The patients were selected and grouped according to the results of the angiography and their age,and they were divided into 3 groups.① premature coronary heart disease group:patients with coronary heart disease diagnosed by coronary angiography and males≤55 years old and females≤65 years old.②mature coronary heart disease group:patients with coronary heart disease diagnosed by coronary angiography and males)55 years old and females)65 years old.③Non-coronary heart disease group:coronary angiography results exclude coronary heart disease and the age of men is≤55 years old,and the age of women is≤65 years old.Record the patient’s general information,including gender,age,height,weight,systolic blood pressure,diastolic blood pressure,heart rate,family history of coronary heart disease,family history of hypertension,smoking,drinking,dyslipidemia,hypertension,diabetes and other diseases,coronary Arterial disease status(number of diseased blood vessels,name of diseased blood vessel,degree of the most severe stenosis of the disease,disease type),inspection and inspection data(such as TG,TC,LDL-C,HDL-C,glycosylated hemoglobin,creatinine,uric acid,LVDd,LVDs,LVPWT,IVST,EF values),TCM syndrome differentiation,and calculation of BMI,left ventricular mass index.Statistical analysis was performed using SPSS 23 statistical software.The count data was expressed as the number of cases(percentage)and subjected to χ2 test;for measurement data,those with normal distribution were expressed as mean±standard deviation,and those with uniform variance were subjected to t-test,and the variances were not uniform to t’-test.For those who did not conform to the normal distribution,they were represented by M(P25,P75),and the rank sum test was performed;SPSS Logistic regression model was used to analyze the possible influencing factors of the premature coronary heart disease group;P<0.05 was used as the difference There is statistical significance.Results1.Compared with the non-coronary heart disease group,the BMI,TC,LDL-C,HDL-C,glycosylated hemoglobin,left ventricular mass index in the premature coronary heart disease group are all high,the EF is low,the proportion of men,combined smoking,hypertension The proportion of diabetes is high,and the difference is statistically significant(P<0.05).2.The classification difference between premature coronary heart disease group and mature coronary heart disease group was statistically significant(P<0.01),and the proportion of myocardial infarction in the premature coronary heart disease group was higher.There was no statistical difference between the two in the number of coronary artery diseased branches and diseased location.The difference between the two types of coronary artery disease was statistically significant(P<0.01).The proportion of type A and B lesions in the premature coronary heart disease group was higher,and the proportion of type C lesions in the mature coronary heart disease group was higher.3.Comparing the distribution of TCM syndrome types,the highest frequency of TCM syndrome types in the premature coronary heart disease group is phlegm turbid obstruction syndrome,followed by heart and blood stasis syndrome,then Qi deficiency and blood stasis syndrome,Qi stagnation and blood stasis syndrome.In the non-coronary heart disease group,the highest frequency of TCM syndromes is Qi stagnation and blood stasis syndrome,to Qi deficiency and blood stasis syndrome,heart and kidney yang deficiency syndrome,and phlegm turbid obstruction syndrome.The difference between the groups was statistically significant(P<0.01),but there was no significant difference in TCM syndrome between the premature coronary heart disease group and the mature coronary heart disease group.Compared with the deficiency and excess syndrome,the premature coronary heart disease group is mostly composed of excess syndrome,although the non-coronary heart disease group is also mainly composed of excess type,but the proportion of deficiency syndrome is higher than that of the premature coronary heart disease group,and the difference is statistically significant(P<0.01).There was no statistically significant difference between the premature coronary heart disease group and the mature coronary heart disease group.4.Compared between the phlegm-turbid syndrome group and the blood-stasis syndrome group,there was no significant difference in the types of coronary artery disease and the number of branches.The phlegm-turbid syndrome group had a higher BMI(P<0.01),while high-density lipoprotein cholesterol,Creatinine and glycosylated hemoglobin were higher in the blood stasis group.There are statistically significant differences in the types of coronary artery disease in patients with three types of syndromes:excess syndrome,combination of deficiency and excess,and deficiency syndrome.The proportion of patients with type B coronary artery disease in the positive group is higher.There is a statistically significant difference in the distribution of TCM syndrome types of different sexes in the premature coronary heart disease group(P<0.01).Males have a high proportion of phlegm and turbidity syndromes,while females have blood stasis syndromes(including heart and blood stasis syndrome,qi deficiency and blood stasis syndrome,Qi stagnation and blood stasis syndrome)accounted for a high proportion.There is also a statistically significant difference between the genders in the excess and deficiency syndrome(P<0.01).The proportion of males with excess evidence is higher,and the proportion of females with of excess and deficiency syndromes and deficiency syndromes is higher.5.Compared with women,men increase the risk of premature coronary heart disease(OR=2.049,85%CI1.087-3.862,P<0.05).Hypertension(OR=2.274,95%CI 1.096-4.142,P<0.01)and diabetes(OR=3.900,95%CI 1.097-9.028,P<0.01)increased the risk of premature coronary heart disease;the higher the left ventricular mass index,the higher the risk of premature coronary heart disease(OR=1.017,95%CI 1.107-1.032,P<0.05);in TCM syndrome,compared with deficiency syndrome,the combination of deficiency and excess and excess syndromes increase the risk of premature coronary heart disease(OR=1.914,95%CI 1.111-3.265,P<0.05),of which the risk of excess syndromes is higher than the deficiency and excess syndromes,and the differences are statistically significant.Conclusion1.Consistent with the risk factors of coronary heart disease,men,hypertension,and diabetes are risk factors for premature coronary heart disease,and left ventricular mass index can be used as a risk factor for premature coronary heart disease.2.The excess syndromes proportion of premature coronary heart disease is high.Phlegm turbidity syndrome and blood stasis syndrome are the main syndrome types.Men prefer phlegm turbidity syndrome and women prefer blood stasis syndrome.Compared with the blood stasis syndrome group,the phlegm turbidity syndrome group had a higher BMI,while the blood stasis syndrome group had higher HDL cholesterol,creatinine,and glycosylated hemoglobin.The number of coronary artery diseased branches and types in the two groups were not difference.