Analysis Of Hemoglobin And Serum Vitamin A,E And D Levels In Premature Infants

Objective:In this study,the levels of hemoglobin(Hb)and vitamin A,E,D(VA,VE,VD)were measured in 199 preterm infants within 24 hours of birth.The aim was to understand the levels of Hb,VA,VE and VD in preterm infants with different gender,mode of birth,birth weight and gestational age and their correlation.To provide reference for the prevention and treatment of anemia and vitamin A,E,D deficiency in premature infants.Methods:A total of 199 cases of preterm infants within 24 hours of birth who were admitted to the Department of Neonatology of the Second Affiliated Hospital of Kunming Medical University from October 2019 to October 2020 were selected as the research subjects.Routine blood examination and serum vitamin A,E and D levels were measured within 1 hour after admission.According to gender,they were divided into boy group and girl group;According to different modes of delivery,they were divided into natural delivery group and cesarean section group.According to different birth weight,birth weight≥2500g was considered as normal birth weight group,birth weight between 1500g and 2499g was considered as low birth weight group,birth weight between 1000g and 1499g was considered as very low birth weight group,and birth weight<1000g was considered as very low birth weight group.According to the relationship between birth weight and gestational age,birth weight in the same gestational age average birth weight above the 90th percentile is greater than the gestational age groups,birth weight in the same average birth weight of the gestational age for between 10～90 percentile for gestational age groups,birth weight in the same gestational age below the average birth weight of the 10th percentile small for gestational age groups.The levels of Hb,VA,VE and VD were analyzed by gender,mode of delivery,birth weight and gestational age.SPSS 24.0 was used for statistical analysis.Results:1.199 premature infants were included in the study,including 105 male infants and 94 female infants;75 cases of natural delivery,124 cases of cesarean delivery;The average birth weight was(2288.70±26.93)g;Average gestational age was[35.57(34.43,36.29)]weeks.2.Hb and vitamin A,E,D levels:average Hb level[184.00(169.00,198.00)]g/L,Hb normal 187 cases(94.0%),anemia in 12 cases(6.0%);The average level of VA[0.13(0.09,0.17)]mg/L,5 patients(2.5%)with normal VA,25 patients(12.6%)with suspected subclinical vitamin A deficiency,103 patients(51.7%)with subclinical vitamin A deficiency,and 66 patients(33.2%)with suspected subclinical vitamin A deficiency.VE level[3.30(2.60,4.40)]mg/L,VE normal 27 cases(13.6%),VE deficiency 172 cases(86.4%);The average level of VD was[14.60(11.00,20.90)]ng/ml.There were 53 patients(26.6%)with suitable VD,44 patients(22.1%)with insufficient VD,98 patients(49.3%)with deficient VD,and 4 patients(2.00%)with severe deficiency.3.Levels of Hb,VA,VE and VD in different sex groups:Serum VE level in the boy group was significantly lower than that in the girl group(Z=-2.353,p<0.05);There were no significant differences in Hb,VA and VD(p>0.05).4.The levels of Hb,VA,VE and Vd in the two modes of delivery groups:the serum VA level of the cesarean section group was significantly lower than that of the natural delivery group(p<0.05),there were no significant differences in serum VE and VD between the two modes of production(p>0.05).5.The levels of Hb,VA,VE and Vd in preterm infants with different birth weight groups:serum VA levels were different among different birth weight groups(p<0.05),the serum VA concentration in LBW group was lower than that in NBW group(p<0.05),and there was no significant difference in the levels of Hb,VE and Vd among the other groups(all p>0.05).6.The levels of Hb,VA,VE and Vd in preterm infants with different birth weight and gestational age:the serum Hb level in the appropriate for gestational age group was less than that in the small for gestational age group(p<0.05),the serum VA level of small gestational age group was significantly lower than that of appropriate for gestational age group(p<0.05),there were no significant differences in VE and VD levels between small gestational age group and suitable gestational age group(p>0.05).7.Correlation between serum vitamin A,E,and D levels:Correlation among serum vitamin A,E and D levels:VA,VE and VD levels were positively correlated with each other(all p<0.05).8.Correlation between vitamin A,E,D levels and the occurrence of anemia:Serum vitamin A,E,D levels were not correlated with the occurrence of anemia(all p>0.05).Conclusion:1.The incidence of subclinical vitamin A deficiency was 51.7%and 33.2%in 199 preterm infants within 24 hours after birth;The incidence of vitamin E deficiency was 86.4%.Vitamin D deficiency was found in 98 cases(49.3%),and severe deficiency was found in 4 cases(2.00%).2.VA deficiency in premature infants may be related to cesarean section,low birth weight and small for gestational age.3.Male infants are more likely to have VE deficiency than female infants.4.Serum VA,VE and VD levels of premature infants were positively correlated with each other.5.There is no correlation between serum vitamin A,E and D levels and the occurrence of anemia in premature infants.