| Objective:By comparing observation of salvia miltiorrhiza blood soup and clopidogrel bisulfate with lower limb arteriosclerosis occlusion disorder in patients with postoperative restenosis 3 months after treatment compared with before the efficient treatment,assessment of salvia miltiorrhiza blood soup for lower limb arteriosclerosis occlusion disease clinical curative effect of postoperative restenosis;By monitoring the objective of the physiological and biochemical index of clinical symptoms such as micro change,combining macroscopic syndrome differentiation of traditional Chinese medicine thinking,explore the salvia miltiorrhiza blood soup for lower limb arteriosclerosis occlusion disease prevention and control of postoperative restenosis corresponding mechanism;To provide evidence and clinical support for traditional Chinese medicin treatment of vascular diseases.Methods: From June 2019 to December 2020,40 patients with postoperative restenosis of lower extremity arteriosclerosis obliterans were selected from the outpatients and wards of vascular and breast surgery in the First Affiliated Hospital of Anhui University of traditional Chinese medicine.They were randomly divided into experimental group(n= 20)and control group(n = 20).Treatment: the control group was given aspirin 100 mg,once a day,clopidogrel bisulfate 75 mg,once a day,and other risk factors were controlled.On the basis of the control group,the experimental group was given the self-made prescription of Danshen Huayu Decoction by Professor Zhou Yu Zhu,twice a day,once in the morning and once in the evening.After 3 months of treatment,ABI,transcutaneous oxygen partial pressure,laser Doppler blood flow monitoring and other clinical efficacy indexes of the two groups were observed and compared,and compared with those before treatment;and the effective rate of the two groups after 3 months of treatment was the main evaluation.Statistical software(SPSS 21.0)was used to analyze the data.Result:1.Before treatment,the general conditions of the two groups,including age,gender,affected limb and ABI,percutaneous oxygen partial pressure,laser Doppler blood flow monitoring,symptom quantification score,were compared.There was no significant difference by t test and non parametric test(P >0.05),which was comparable.2.Curative effect analysis(1)The ABI of the experimental group after treatment was significantly higher than that before treatment,P<0.05 ABI in the control group after treatment was higher than that before treatment,P<0.05 by two sample paired t-test.After treatment,the ABI of the experimental group was better than that of the control group,and the independent sample t test showed that there was significant difference(P<0.05).(2)In the experimental group,after treatment,the transcutaneous oxygen partial pressure was significantly higher than that before treatment(P<0.05).In the control group,after treatment,the transcutaneous oxygen partial pressure was higher than that before treatment,and there was statistical difference between the two samples by paired t test(P<0.05).After treatment,the improvement of percutaneous oxygen partial pressure in the experimental group was significantly better than that in the control group,P < 0.05 by independent sample t test.(3)After treatment,the laser Doppler blood flow monitoring in the experimental group was significantly improved compared with that before treatment,and the two samples paired t test showed that there was a statistical difference(P<0.05).In the control group,the laser Doppler blood flow monitoring after treatment was significantly improved compared with that before treatment,and there was statistical difference between the two samples by paired t test(P<0.05).After treatment,the increase of laser Doppler blood flow monitoring in the experimental group was significantly better than that in the control group(P<0.05).(4)The scores of pain,skin color,claudication,skin temperature,transcutaneous partial pressure of oxygen,ABI and Doppler ultrasound were compared between the experimental group and the control group before and after treatment,and there was significant difference(P<0.05).After treatment,the experimental group compared with the control group,claudication,transcutaneous oxygen partial pressure,ABI score,by non parametric test,P<0.05,with statistical difference;pain,skin color,skin temperature,Doppler ultrasound score,by non parametric test,P>0.05,without statistical difference.Conclusion:(1)The two groups of treatment methods can improve the ABI,percutaneous partial pressure of oxygen,laser Doppler blood flow perfusion and other clinical indicators in the restenosis of lower extremity arteriosclerosis obliterans,and the effect of Danshen Huayu decoction is more significant.(2)Two groups of treatment methods for lower extremity arteriosclerosis obliterans postoperative restenosis symptom quantitative score all aspects have improved,in which Danshen Huayu Decoction for intermittent claudication effect is more obvious than simple western medicine treatment. |
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