The Effect Of Yu Ping Feng Powder On ICAM-1 In Allergic Nasal Mucosa

Objectove: Observe the effects of modification Jude Screen powder on ICAM-1 rat in nosal mucosa of rats with allIergic rhinitis(AR),to stady the treating mechanism of traditional Chinese medicine(TCM).Method: Forty-eight rats were randomly devided into four groups:normoral group,AR groups,westen medicine groups,a:id traditional Chinese medicine groups.record the nasal symptoms such as sneezing and scratchingnose during the treatment,compare them to the quanlified indexes of comperison groups.After killingthe rats ,observe the pathological changes of the nasal mucosa of them in each group,and test the expression of ICAM-1.Result: 1 .Observation of nasal symptoms on the AR rats before and after treatment and marks showed that ,before treatment, the nasal symptoms of normal group had significant differences with other three groups, after treatment,symptoms of western medicine group had no obvious difference compared with that of TCM group(P>0.05),while both had lower marks thanmode group(P<0.01),and are higher than normal group(P<0.05).2. Pathological observation of the nasal septum mucosa: comparison of EOS positive rate of the nasal septum mucosa, western medicine group had no statistical significance with TCM group(p>0.05),but both had evident difference with AR group and normal group(P<0.01).3.Test of ICAM-1: Count the positive cell number of ICAM-1 under photo-microscope , western medicine group had no statistical significance with TCM group(p>0.05),and both had significant difference with AR group and normal group(P<0.01).Conclusion: By restraining the expression of ICAM-1 in nasal mucosa of rats with AR, Yu Ping Feng powder can decrease the infliltration of EOS in rats' nasal mucosa,achieve treating purpose.