| Objective:Clinical observation on the morning peak phenomenon of hypertension with compound Tianma antihypertensive granules in the treatment of yin deficiency and yang hyperactivity Method:The selection of Chinese medicine of 60 cases of yin deficiency and yang hyperactivity in patients with primary hypertension,and dynamic monitoring of morning blood pressure peak is greater than or equal to 50 mmHg.The random method,divided into treatment group and control group,two groups were treated with conventional western medicine antihypertensive treatment,the treatment group in the conventional western medicine with Tianma compound Jiangya granule,4 weeks,two groups were observed before and after the experiment the morning blood pressure peak level,morning peak cure rate,24 H dynamic changes of blood pressure,RAAS and other laboratory indicators of change index.Result:1.The degree of morning peak of blood pressure was compared: after treatment,the level of blood pressure in the morning peak of the two groups was significantly lower than that before the treatment(P < 0.01).Group comparison: compared with the control group,the reduction in the treatment group was significant,and the difference was statistically significant(P < 0.05).2.Blood pressure morning peak cure rate comparison: after treatment,the treatment group: the morning peak cure number in 29 cases,the number of uncured cases 1 cases,the morning peak cure rate is 96.67%.The control group: 22 cases were cured in the morning peak,8 cases were uncured,the cure rate of the morning peak was 73.33%,andthe statistical difference was found by 2 tests(P < 0.05).3.Comparison of ambulatory blood pressure data: after treatment,in group comparison: compared with before treatment,the two groups of parameters 24 hSBP,24hDBP,dSBP,nSBP,dDBP and nDBP were significantly decreased,with statistically significant difference(P < 0.01).Group comparison: compared with the control group,the decrease of 24 hSBP,dSBP and nSBP in the treatment group was significant,and the difference was statistically significant(P < 0.05).4.The efficacy of TCM syndrome: TCM symptom score: after treatment,the total score of TCM symptoms in the two groups decreased to different degrees compared with those before treatment,and there was a difference in Statistics(P < 0.01).And compared with the control group,the curative effect of the treatment group was more significant than that in the treatment group(P < 0.05).The total curative effect of TCM syndrome: compared with the control group,the total effective rate of the treatment group was more prominent,and the difference was statistically significant(P < 0.05).5.RAAS laboratory index: comparison group after treatment than before treatment,renin in contrast to the two groups data with statistical significance(P>0.05);and no angiotensin II(AngII),aldosterone(ALD)levels decreased significantly,with statistical significant(P < 0.05).After treatment,compared with the control group,the reduction of AngII and ALD was more prominent in the treatment group than in the control group,and the difference was statistically significant(P < 0.05).6.Safety index: comparison of heart rate changes: there was no statistical difference between the two groups before treatment(P>0.05);after treatment group comparison: the treatment group was statistically different(P < 0.05),but there was no statistical difference between the control group(P>0.05),and the comparison betweenthe groups was better than the control group(P < 0.).05).During the treatment,other safety indicators were not obviously abnormal,and the adverse symptoms were rare.Conclusion:Compound Tianma Jiangya granule has significant effect on lowering blood pressure morning peak level of yin deficiency yang hyperactivity syndrome,has obvious effect of reducing blood pressure,and can improve clinical symptoms and safety of traditional Chinese medicine.It is worthy of further research and popularization. |
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