Prescription And Medication Rule Of Professor Liu Jianqiu In Differetiating And Treating Copd In Stable Stage Based On The Traditional Chinese Medicine Inheritance Support System

Objective:We systematically analyzed the outpatient medical records of Professor Jianqiu Liu in the treatment of stable phase of chronic obstructive pulmonary disease with insomnia by using the Traditional Chinese Medicine Inheritance Support System(V3.0),and summarized Professor Liu’s medication,syndrome types and core formula rules for the treatment of stable phase of chronic obstructive pulmonary disease with insomnia,in order to provide a referenfce for the treatment of stable phase of chronic obstructive pulmonary disease with insomnia by traditional Chinese medicine.Methods:We collected the medical records of patients who visited the Respiratory Clinic of the First Affiliated Hospital of Heilongjiang University of Chinese Medicine from Novem-ber 2021 to January 2023 and were diagnosed as stable phase of chronic obstructive pulmonary disease with insomnia by Professor Jianqiu Liu and met the inclusion criteria.187 cases of outpatient electronic medical records(symptoms,treatment principles and methods,Chinese herbal medicine name,etc.)were standardized and entered into the Traditional Chinese Medicine Inheritance Support System(V3.0).Then we used association rules and cluster analysis to excavate Professor Jianqiu Liu’s medication formula for the treatment of stable phase of chronic obstructive pulmonary disease with insomnia.Results:1.A total of 187 patients were included in this study,including 126females(67.38%)and 61 males(32.62%).The age distribution of 60-69-yearolds is the largest(39.04%).2.In 187 medical records,there were 4 syndromes: heart-liver deficiency,spleen deficiency and phlegm-dampness,liver-qi-stagnation,and internal disturbance of phlegm-heat.3.The main symptoms were insomnia,expectoration,cough,palpitation,tinnitus,vertigo,dysphoria in chestpalms-soles,loose stools,spontaneous sweating,anorexia,dry throat,irritability,depression,wheeziness,etc.4.The treatment principles and methods are mainly tranquilizing the mind,Ningxin,relieving asthma,reducing phlegm,relieving cough,Yangxin,Bugan,Jianpi,eliminating dampness,tonifying Qi,Shugan,regulating Qi,etc.5.Commonly used drugs are mainly Semen Ziziphi Spinosae,Poria Cocos,Semen Ginkgo,Pinellia Ternata,Semen Trmeniacae Amara,Bupleurum Chinense,Radix Codonopsis,Dried Tangerine Peel,Milkvetch Root,Macrocephalae Rhizoma,etc.The drug efficacy is mainly to dissipate phlegm,relieve cough and asthma,tonify deficiency,tranquilize the mind,and regulate Qi.The four qi are mainly warm,flat and cold.The five flavors are mainly bitter,sweet and pungent.It belongs to the lung,spleen,heart,stomach,and liver meridians.6.After drug association rules,the commonly used drug combinations are Semen Ziziphi Spinosae-Poria Cocos,Pinellia Ternata-Dried Tangerine PeelPoria Cocos,Radix Codonopsis-Milkvetch Root,Semen Ginkgo-Bamboo Shavings,Bupleurum Chinense-Poria Cocos-Semen Ziziphi Spinosae,etc.7.Cluster analysis yielded five core groups: Group 1: Semen Ziziphi Spinosae,Poria Cocos,Ophiopogon Japonicus,Os Draconis,Semen Boitae,Oyster Shell;Group 2: Radix Codonopsis,Milkvetch Root,Pinellia Ternata,Dried Tangerine Peel,Macrocephalae Rhizoma,Poria Cocos;Group 3: Radix Codonopsis,Sichuan Lovage Rhizome,Poria Cocos,Macrocephalae Rhizoma,Bamboo Shavings,Tatarian Aster Root;Group 4: Bupleurum Chinense,Turmeric Root Tuber,Sichuan Lovage Rhizome,Macrocephalae Rhizoma,Semen Ziziphi Spinosae,Poria Cocos;Group 5: Semen Ginkgo,Bamboo Shavings,Semen Trmeniacae Amara,Poria Cocos,Dried Tangerine Peel,Macrocephalae Rhizoma.Conclusions:1.Professor Jianqiu Liu divides stable phase of chronic obstructive pulmonary disease with insomnia into 4 syndromes: heart-liver deficiency,spleen deficiency and phlegm-dampness,liver-qi-stagnation,and internal disturbanc-e of phlegm-heat.2.Professor Jianqiu Liu’s therapeutic principles and methods for treating this disease are tranquilizing the mind,Ningxin,relieving asthma,reducing phlegm,relieving cough,Yangxin,Bugan,Jianpi,eliminating dampness,tonifying Qi,Shugan,regulating Qi,etc.High-frequency drugs are Semen Ziziphi Spinosae,Poria Cocos,Semen Ginkgo,Pinellia Ternata,Semen Trmeniacae Amara,Bupleurum Chinense,Radix Codonopsis,Dried Tangerine Peel,Milkvetch Root,Macrocephalae Rhizoma and so on.The four qi are mainly warm,flat and cold.The five flavors are mainly bitter,sweet and pungent.It belongs to the lung,spleen,heart,stomach,and liver meridians.Commonly used drug combinations were obtained by drug association rules combined with actual clinical practice: Semen Ziziphi Spinosae-Poria Cocos,Pinellia Ternata-Dried Tangerine Peel-Poria Cocos,Radix CodonopsisMilkvetch Root,Semen Ginkgo-Bamboo Shavings,Bupleurum ChinensePoria Cocos-Semen Ziziphi Spinosae,etc.Five groups of core formulations were obtained by cluster analysis.3.Professor Jianqiu Liu believes that insomnia in stable phase of chronic obstructive pulmonary disease is closely related to deficiency of qi,blood,yin and yang in heart,liver,spleen and lung,and is not unrelated to phlegm,liver depression and other factors.The treatment of this disease takes into account both tonifying deficiency and eliminating pathogenic factors.The formulation is flexible and combines syndrome differentiation with symptomatic treatment.