Study Of The Regulation On The Expression Of VEGF And Its Receptor SFlt-1 By Hypoxia Inducible Factor And The Role Of It In The Pathogenesis Of Preeclampsia

Placenta is the organ responsible for the exchange of gas and nutrition between mother and fetus, as well as removing metabolic products. Coordinative villous angiogenesis is closely correlated with fetal development and growth. Morphological study indicated that hypertensive disorder complicating pregnancy, intrauterus growth retardation and so on diseases possess abnormal villous development, reduced vessles and functional imparment. During the early pregnancy , placentataion occurs in a relatively hypoxia enviorment, consistsing with the conclusion from in vivo study that cytotrophoblasts diaply phenotypical transformation along their invasive way by oxygen depending manner, in vitro study indicated that cytotrophoblasts would proliferate under hypoxia condition and transform into invasive phenotype under higher oxygen pressure, which benefiting for their migration into endometrium and the spiral arterial endothelial cells in the superior 1/3 endometrium,it is called "physiological remolding "that is advantageous for the blood and nutrition supply to the fetus. Different from cancer cells, cytotrophoblastic activity is precisely regulated by the microenviron-mental factors, such as oxygen pressure, hormone, cytokines, growth factors, as well as extracellular glycoprotein and transcription factors, previous study demonstrated that as one of the important regulators, oxygen might plays the key role in the phenotypic tranformation of cytotrophoblastic and placental angiogenesis and...